Congenital cytomegalovirus infection
Congenital cytomegalovirus (cCMV) is cytomegalovirus (CMV) infection in a newborn baby. Most have no symptoms. Some affected babies are small. Other signs and symptoms include a rash, jaundice, hepatomegaly, retinitis, and seizures. It may lead to loss of hearing or vision, developmental disability, or a small head.
| Congenital cytomegalovirus infection | |
|---|---|
| Micrograph of a cytomegalovirus (CMV) infection of the placenta (CMV placentitis). The characteristic large nucleus of a CMV infected cell is seen off-centre at the bottom-right of the image. H&E stain | |
| Specialty | Pediatrics |
CMV is a member of the virus family herpesviridae and is the most common congenital intrauterine infection. cCMV is caused when a mother is infected with CMV in pregnancy and passes it to her unborn baby. The risk of severe disease is greatest if the mother is infected in early pregnancy; most have no symptoms. Diagnosis is by tests in the first 3-weeks after birth; on preferably urine, although saliva and blood can be used. The chance of infection is reduced by hand washing, and avoiding touching saliva or urine of very young children.
Worldwide the condition is common, and likely underreported.