Collagen, type III, alpha 1

COL3A1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2V53, 3DMW, 4AE2, 4AEJ, 4AK3, 4GYX
Identifiers
Aliases	COL3A1, EDS4A, collagen type III alpha 1, collagen type III alpha 1 chain, EDSVASC, PMGEDSV
External IDs	OMIM: 120180 MGI: 88453 HomoloGene: 55433 GeneCards: COL3A1
Gene location (Human)
Chr.	Chromosome 2 (human)
End	189,012,746 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	45,388,866 bp
RNA expression pattern
	Top expressed in
	parietal pleura; ; visceral pleura; ; periodontal fiber; ; stromal cell of endometrium; ; saphenous vein; ; gallbladder; ; pylorus; ; smooth muscle tissue; ; vulva; ; synovial joint;
	Top expressed in
	conjunctival fornix; ; vas deferens; ; cervix; ; belly cord; ; calvaria; ; ascending aorta; ; semi-lunar valve; ; aortic valve; ; body of femur; ; skin of abdomen;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	metal ion binding; integrin binding; protein binding; platelet-derived growth factor binding; SMAD binding; extracellular matrix structural constituent; protease binding; extracellular matrix structural constituent conferring tensile strength;
Cellular component	collagen; endoplasmic reticulum lumen; extracellular space; collagen type III trimer; extracellular matrix; extracellular region; collagen-containing extracellular matrix;
Biological process	positive regulation of Rho protein signal transduction; skeletal system development; negative regulation of neuron migration; response to cytokine; response to mechanical stimulus; human ageing; extracellular matrix organization; platelet activation; heart development; peptide cross-linking; negative regulation of immune response; blood vessel development; regulation of immune response; cerebral cortex development; collagen catabolic process; cellular response to amino acid stimulus; integrin-mediated signaling pathway; response to radiation; cell-matrix adhesion; digestive tract development; transforming growth factor beta receptor signaling pathway; aorta smooth muscle tissue morphogenesis; skin development; collagen fibril organization; wound healing; supramolecular fiber organization;
	Sources:Amigo / QuickGO
Orthologs
	1281
	12825
	ENSG00000168542
	ENSMUSG00000026043
	P02461
	P08121
	NM_000090; NM_001376916
	NM_009930
	NP_000081
	NP_034060
	Wikidata
View/Edit Human	View/Edit Mouse

Type III Collagen is a homotrimer, or a protein composed of three identical peptide chains (monomers), each called an alpha 1 chain of type III collagen. Formally, the monomers are called collagen type III, alpha-1 chain and in humans are encoded by the COL3A1 gene. Type III collagen is one of the fibrillar collagens whose proteins have a long, inflexible, triple-helical domain.

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