Ethinylestradiol/cyproterone acetate

Ethinylestradiol/cyproterone acetate (EE/CPA), also known as co-cyprindiol and sold under the brand names Diane and Diane-35 among others, is a combination of ethinylestradiol (EE), an estrogen, and cyproterone acetate (CPA), a progestin and antiandrogen, which is used as a birth control pill to prevent pregnancy in women. It is also used to treat androgen-dependent conditions in women such as acne, seborrhea, excessive facial/body hair growth, scalp hair loss, and high androgen levels associated with ovaries with cysts. The medication is taken by mouth once daily for 21 days, followed by a 7-day free interval.

Ethinylestradiol/cyproterone acetate
Ethinylestradiol (top) and
cyproterone acetate (bottom)
Combination of
EthinylestradiolEstrogen
Cyproterone acetateProgestogen; Antiandrogen
Clinical data
Trade namesDiane, Diane-35, others
Other namesEE/CPA; Co-cyprindiol; SHB 209 AB; SHB 209 AE; SH-81041
Routes of
administration		By mouth
Drug classEstrogen; Progestogen; Antiandrogen
ATC code
Legal status
Legal status
  • US: ℞-only
  • EU: Rx-only
Identifiers
CAS Number
PubChem CID
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