Amoxicillin/clavulanic acid

Amoxicillin/clavulanic acid
Combination of
Amoxicillin	Penicillin antibiotic
Clavulanic acid	Beta-lactamase inhibitor
Clinical data
Trade names	Augmentin, Clavulin, Amoclan, others
Other names	co-amoxiclav, amox-clav
AHFS/Drugs.com	Monograph
MedlinePlus	a685024
License data	US DailyMed: Amoxicillin clavulanate;
Pregnancy; category	AU: B1;
Routes of; administration	By mouth, intravenous
ATC code	J01CR02 (WHO) QJ01CR02 (WHO);
Legal status
Legal status	AU: S4 (Prescription only); CA: ℞-only; UK: POM (Prescription only); US: ℞-only;
Identifiers
CAS Number	74469-00-4; 74428-36-7;
PubChem CID	6435924;
ChemSpider	4940608;
KEGG	D06485;
ChEMBL	ChEMBL1697738;
CompTox Dashboard (EPA)	DTXSID40225477 ;
Chemical and physical data
Formula	C24H27KN4O10S
Molar mass	602.66 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC1(C(N2C(S1)C(C2=O)NC(=O)C(C3=CC=C(C=C3)O)N)C(=O)O)C.C1C2N(C1=O)C(C(=CCO)O2)C(=O)[O-].[K+];
	InChI InChI=DWHGNUUWCJZQHO-ZVDZYBSKSA-M; Key:1S/C16H19N3O5S.C8H9NO5.K/c1-16(2)11(15(23)24)19-13(22)10(14(19)25-16)18-12(21)9(17)7-3-5-8(20)6-4-7;10-2-1-4-7(8(12)13)9-5(11)3-6(9)14-4;/h3-6,9-11,14,20H,17H2,1-2H3,(H,18,21)(H,23,24);1,6-7,10H,2-3H2,(H,12,13);/q;;+1/p-1/b;4-1-;/t9-,10-,11+,14-;6-,7-;/m11./s1;
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Amoxicillin/clavulanic acid, also known as co-amoxiclav or amox-clav, sold under the brand name Augmentin, among others, is an antibiotic medication used for the treatment of a number of bacterial infections. It is a combination consisting of amoxicillin, a β-lactam antibiotic, and potassium clavulanate, a β-lactamase inhibitor. It is specifically used for otitis media, streptococcal pharyngitis, pneumonia, cellulitis, urinary tract infections, and animal bites. It is taken by mouth or by injection into a vein.

Common side effects include diarrhea, vomiting, and allergic reactions. It also increases the risk of yeast infections, headaches, and blood clotting problems. It is not recommended in people with a history of a penicillin allergy. It is relatively safe for use during pregnancy.

Amoxicillin/clavulanic acid was approved for medical use in the United States in 1984. It is on the World Health Organization's List of Essential Medicines. The World Health Organization classifies amoxicillin/clavulanic-acid as critically important for human medicine. It is available as a generic medication. In 2021, it was the 115th most commonly prescribed medication in the United States, with more than 5 million prescriptions.

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