Chloramphenicol
Chloramphenicol is an antibiotic useful for the treatment of a number of bacterial infections. This includes use as an eye ointment to treat conjunctivitis. By mouth or by injection into a vein, it is used to treat meningitis, plague, cholera, and typhoid fever. Its use by mouth or by injection is only recommended when safer antibiotics cannot be used. Monitoring both blood levels of the medication and blood cell levels every two days is recommended during treatment.
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| Trade names | Chloromycetin, Abeed, others |
| Other names | C/CHL/CL |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a608008 |
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| Routes of administration | Topical (eye drops), by mouth, intravenous therapy (IV), intramuscular injection (IM) |
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| Bioavailability | 75–90% |
| Protein binding | 60% |
| Metabolism | Liver |
| Elimination half-life | 1.6–3.3 hours |
| Excretion | Kidney (5–15%), faeces (4%) |
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| ECHA InfoCard | 100.000.262 |
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| Formula | C11H12Cl2N2O5 |
| Molar mass | 323.13 g·mol−1 |
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Common side effects include bone marrow suppression, nausea, and diarrhea. The bone marrow suppression may result in death. To reduce the risk of side effects treatment duration should be as short as possible. People with liver or kidney problems may need lower doses. In young infants, a condition known as gray baby syndrome may occur which results in a swollen stomach and low blood pressure. Its use near the end of pregnancy and during breastfeeding is typically not recommended. Chloramphenicol is a broad-spectrum antibiotic that typically stops bacterial growth by stopping the production of proteins.
Chloramphenicol was discovered after being isolated from Streptomyces venezuelae in 1947. Its chemical structure was identified and it was first synthesized in 1949. It is on the World Health Organization's List of Essential Medicines. It is available as a generic medication.