Charles Brenner (biochemist)
Charles Brenner (born October 30, 1961) is the inaugural Alfred E Mann Family Foundation Chair of the Department of Diabetes & Cancer Metabolism at the Beckman Research Institute of the City of Hope National Medical Center. Brenner previously held the Roy J. Carver Chair in Biochemistry and was head of biochemistry at the University of Iowa.
Charles Brenner | |
|---|---|
| Born | October 30, 1961 |
| Nationality | American |
| Alma mater | Wesleyan University (BA) Stanford University (PhD) Brandeis University |
| Known for | Discovery and characterization of nicotinamide riboside as a vitamin |
| Awards | Fellow of the American Association for the Advancement of Science |
| Scientific career | |
| Fields | Enzymology Metabolism |
| Institutions | City of Hope National Medical Center University of Iowa Dartmouth Medical School Thomas Jefferson University |
| Thesis | Specificity and Activity of the Kex2 Protease: From Yeast Genetics to Enzyme Kinetics (1993) |
| Doctoral advisor | Robert S. Fuller |
| Other academic advisors | Gregory A. Petsko Dagmar Ringe |
| Notable students | Peter A. Belenky, Samuel A.J. Trammell |
| Website | brennerlab |
Brenner is a major contributor in the field of nicotinamide adenine dinucleotide (NAD) metabolism and has developed targeted, quantitative methods for NAD metabolomics. Brenner discovered eukaryotic nicotinamide riboside (NR) kinase and nucleosidase pathways to NAD. Brenner's work includes the first human trial of NR, which demonstrated safe oral availability as an NAD+ precursor. He has characterized ways in which NAD is disrupted by diseases and metabolic stress.