Ceruloplasmin

CP
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1KCW, 2J5W, 4EJX, 4ENZ
Identifiers
Aliases	CP, CP-2, ceruloplasmin (ferroxidase), Ceruloplasmin, AB073614
External IDs	OMIM: 117700 MGI: 88476 HomoloGene: 75 GeneCards: CP
EC number	1.16.3.1
Gene location (Human)
Chr.	Chromosome 3 (human)
End	149,221,829 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	20,063,309 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; palpebral conjunctiva; ; bronchial epithelial cell; ; ascending aorta; ; right coronary artery; ; minor salivary glands; ; Achilles tendon; ; rectum; ; spleen; ; lymph node;
	Top expressed in
	left lobe of liver; ; ciliary body; ; carotid body; ; right lung lobe; ; left lung; ; gallbladder; ; white adipose tissue; ; iris; ; ankle joint; ; left lung lobe;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	chaperone binding; metal ion binding; ferroxidase activity; oxidoreductase activity; copper ion binding; oxidoreductase activity, acting on metal ions;
Cellular component	blood microparticle; extracellular region; lysosomal membrane; extracellular exosome; extracellular space; endoplasmic reticulum lumen; plasma membrane;
Biological process	ion transport; copper ion transport; cellular iron ion homeostasis; post-translational protein modification; transport; iron ion transport; iron ion homeostasis;
	Sources:Amigo / QuickGO
Orthologs
	1356
	12870
	ENSG00000047457
	ENSMUSG00000003617
	P00450
	Q61147
	NM_000096
	NM_001042611; NM_001276248; NM_001276250; NM_007752; NM_001374677
	NP_000087
	NP_001263177; NP_001263179; NP_031778; NP_001361606
	Wikidata
View/Edit Human	View/Edit Mouse

Ceruloplasmin (or caeruloplasmin) is a ferroxidase enzyme that in humans is encoded by the CP gene.

Ceruloplasmin is the major copper-carrying protein in the blood, and in addition plays a role in iron metabolism. It was first described in 1948. Another protein, hephaestin, is noted for its homology to ceruloplasmin, and also participates in iron and probably copper metabolism.

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