Ceftazidime/avibactam

Ceftazidime/avibactam, sold under the brand name Avycaz among others, is a fixed-dose combination medication composed of ceftazidime, a cephalosporin antibiotic, and avibactam, a β-lactamase inhibitor. It is used to treat complicated intra-abdominal infections, urinary tract infections, and pneumonia. It is only recommended when other options are not appropriate. It is given by infusion into a vein.

Common side effect include nausea, fever, liver problems, headache, trouble sleeping, and pain at the site of infusion. Severe side effects may include anaphylaxis, seizures, and Clostridioides difficile-associated diarrhea. While use appears to be safe in pregnancy the medication has not been well studied in this group. Doses should be adjusted in those with kidney problems. Ceftazidime works by interfering with the building of the bacterial cell wall while avibactam works by preventing ceftazidime's breakdown.

The combination was approved for medical use in the United States and the European Union in 2015. It is on the World Health Organization's List of Essential Medicines. Resistances are increasingly been reported with United States, Greece and Italy accounting for 80% of cases.