Cathepsin H

CTSH
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1BZN
Identifiers
Aliases	CTSH, ACC-4, ACC-5, CPSB, minichain, ACC4, ACC5, cathepsin H
External IDs	OMIM: 116820 MGI: 107285 HomoloGene: 36159 GeneCards: CTSH
Gene location (Human)
Chr.	Chromosome 15 (human)
End	78,949,574 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	89,958,142 bp
RNA expression pattern
	Top expressed in
	optic nerve; ; kidney tubule; ; lower lobe of lung; ; bronchial epithelial cell; ; kidney; ; visceral pleura; ; renal medulla; ; monocyte; ; lymph node; ; upper lobe of lung;
	Top expressed in
	left lung lobe; ; right lung lobe; ; yolk sac; ; parotid gland; ; proximal tubule; ; cervix; ; left lobe of liver; ; kidney; ; spleen; ; corneal stroma;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	peptidase activator activity involved in apoptotic process; cysteine-type peptidase activity; HLA-A specific activating MHC class I receptor activity; endopeptidase activity; protein binding; cysteine-type endopeptidase activator activity involved in apoptotic process; cysteine-type endopeptidase activity; aminopeptidase activity; serine-type endopeptidase activity; hydrolase activity; thyroid hormone binding; peptidase activity;
Cellular component	cytosol; alveolar lamellar body; lysosome; extracellular exosome; multivesicular body lumen; extracellular region; extracellular space; secretory granule lumen; intracellular membrane-bounded organelle; tertiary granule lumen; ficolin-1-rich granule lumen; cytoplasmic ribonucleoprotein granule; collagen-containing extracellular matrix;
Biological process	surfactant homeostasis; antigen processing and presentation; adaptive immune response; bradykinin catabolic process; response to retinoic acid; membrane protein proteolysis; positive regulation of cell migration; ERK1 and ERK2 cascade; zymogen activation; neuropeptide catabolic process; positive regulation of epithelial cell migration; positive regulation of apoptotic signaling pathway; negative regulation of apoptotic process; proteolysis; positive regulation of angiogenesis; positive regulation of peptidase activity; positive regulation of gene expression; protein destabilization; cellular response to thyroid hormone stimulus; positive regulation of cell population proliferation; immune response-regulating signaling pathway; proteolysis involved in cellular protein catabolic process; metanephros development; dichotomous subdivision of terminal units involved in lung branching; T cell mediated cytotoxicity; apoptotic process; activation of cysteine-type endopeptidase activity involved in apoptotic process; neutrophil degranulation;
	Sources:Amigo / QuickGO
Orthologs
	1512
	13036
	ENSG00000103811
	ENSMUSG00000032359
	P09668
	P49935
	NM_004390; NM_148979; NM_001319137
	NM_007801; NM_001312649
	NP_001306066; NP_004381
	NP_001299578; NP_031827
	Wikidata
View/Edit Human	View/Edit Mouse

Cathepsin H is a protein that in humans is encoded by the CTSH gene.

The protein encoded by this gene is a cysteine cathepsin, a lysosomal cysteine protease important in the overall degradation of lysosomal proteins. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. The encoded protein, which belongs to the peptidase C1 protein family, can act both as an aminopeptidase and as an endopeptidase. Increased expression of this gene has been correlated with malignant progression of prostate tumors. Two transcript variants encoding different isoforms have been found for this gene.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.