Carboxypeptidase B2

CPB2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3D66, 3D67, 3D68, 3LMS, 4P10, 5HVG, 5HVH, 5HVF
Identifiers
Aliases	CPB2, CPU, PCPB, TAFI, carboxypeptidase B2
External IDs	OMIM: 603101 MGI: 1891837 HomoloGene: 55610 GeneCards: CPB2
Gene location (Human)
Chr.	Chromosome 13 (human)
End	46,105,033 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	75,520,995 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; lower lobe of lung; ; corpus epididymis; ; right lung; ; gallbladder; ; upper lobe of lung; ; upper lobe of left lung; ; visceral pleura; ; caput epididymis; ; corpus callosum;
	Top expressed in
	left lobe of liver; ; secondary oocyte; ; urethra; ; sexually immature organism; ; morula; ; rete testis; ; renal corpuscle; ; ureter; ; islet of Langerhans; ; epithelium of stomach;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	metal ion binding; peptidase activity; hydrolase activity; zinc ion binding; carboxypeptidase activity; metallopeptidase activity; metallocarboxypeptidase activity;
Cellular component	extracellular exosome; extracellular space; extracellular region;
Biological process	blood coagulation; negative regulation of hepatocyte proliferation; positive regulation of extracellular matrix constituent secretion; liver regeneration; cellular response to glucose stimulus; negative regulation of plasminogen activation; negative regulation of fibrinolysis; response to heat; hemostasis; proteolysis; fibrinolysis; regulation of complement activation;
	Sources:Amigo / QuickGO
Orthologs
	1361
	56373
	ENSG00000080618
	ENSMUSG00000021999
	Q96IY4
	Q9JHH6
	NM_016413; NM_001278541; NM_001872
	NM_019775
	NP_001265470; NP_001863
	NP_062749
	Wikidata
View/Edit Human	View/Edit Mouse

Carboxypeptidase B2 (CPB2), also known as carboxypeptidase U (CPU), plasma carboxypeptidase B (pCPB) or thrombin-activatable fibrinolysis inhibitor (TAFI), is an enzyme that, in humans, is encoded by the gene CPB2.

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