Carboxylesterase type B
Carboxylesterase, type B is a family of evolutionarily related proteins that belongs to the superfamily of proteins with the Alpha/beta hydrolase fold.
| Carboxylesterase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
Structure of ethylphosphorylated Butyrylcholinesterase. | |||||||||
| Identifiers | |||||||||
| Symbol | COesterase | ||||||||
| Pfam | PF00135 | ||||||||
| InterPro | IPR002018 | ||||||||
| PROSITE | PDOC00112 | ||||||||
| SCOP2 | 1acj / SCOPe / SUPFAM | ||||||||
| OPM superfamily | 127 | ||||||||
| OPM protein | 1p0i | ||||||||
| CDD | cd00312 | ||||||||
| |||||||||
Higher eukaryotes have many distinct esterases. The different types include those that act on carboxylic esters (EC 3.1.1). Carboxyl-esterases have been classified into three categories (A, B and C) on the basis of differential patterns of inhibition by organophosphates. The sequence of a number of type-B carboxylesterases indicates that the majority are evolutionarily related. As is the case for lipases and serine proteases, the catalytic apparatus of esterases involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.