Bile salt-dependent lipase

CEL
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1F6W, 1JMY
Identifiers
Aliases	CEL, BAL, BSDL, BSSL, CELL, CEase, FAP, FAPP, LIPA, MODY8, Bile salt-dependent lipase, carboxyl ester lipase
External IDs	OMIM: 114840 MGI: 88374 HomoloGene: 37529 GeneCards: CEL
Gene location (Human)
Chr.	Chromosome 9 (human)
End	133,071,861 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	28,453,415 bp
RNA expression pattern
	Top expressed in
	body of pancreas; ; pituitary gland; ; anterior pituitary; ; corpus epididymis; ; caput epididymis; ; duodenum; ; right uterine tube; ; right lobe of liver; ; kidney; ; right coronary artery;
	Top expressed in
	pyloric antrum; ; islet of Langerhans; ; epithelium of stomach; ; duodenum; ; sexually immature organism; ; mucous cell of stomach; ; tracheobronchial tree; ; left lobe of liver; ; spleen; ; large intestine;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	heparin binding; acylglycerol lipase activity; catalytic activity; protein binding; hydrolase activity; hydrolase activity, acting on ester bonds; carboxylic ester hydrolase activity; triglyceride lipase activity; sterol esterase activity; signaling receptor activity; neurexin family protein binding;
Cellular component	cytoplasm; extracellular region; extracellular exosome; extracellular space; integral component of plasma membrane; cell surface; synapse; presynapse;
Biological process	fatty acid catabolic process; lipid digestion; protein esterification; lipid metabolism; cholesterol catabolic process; pancreatic juice secretion; intestinal lipid catabolic process; lipid catabolic process; intestinal cholesterol absorption; triglyceride metabolic process; neuron cell-cell adhesion; synaptic vesicle endocytosis; modulation of chemical synaptic transmission; postsynaptic membrane assembly; presynaptic membrane assembly;
	Sources:Amigo / QuickGO
Orthologs
	1056
	12613
	ENSG00000170835
	ENSMUSG00000026818
	P19835
	Q64285
	NM_001807
	NM_009885
	NP_001798
	NP_034015
	Wikidata
View/Edit Human	View/Edit Mouse

Bile salt-dependent lipase (or BSDL), also known as carboxyl ester lipase (or CEL) is an enzyme produced by the adult pancreas and aids in the digestion of fats. Bile salt-stimulated lipase (or BSSL) is an equivalent enzyme found within breast milk. BSDL has been found in the pancreatic secretions of all species in which it has been looked for. BSSL, originally discovered in the milk of humans and various other primates, has since been found in the milk of many animals including dogs, cats, rats, and rabbits.

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