Carbonic anhydrase III, muscle specific

CA3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1Z93, 1Z97, 2HFW, 3UYN, 3UYQ
Identifiers
Aliases	CA3, CAIII, Car3, carbonic anhydrase 3
External IDs	OMIM: 114750 MGI: 88270 HomoloGene: 31298 GeneCards: CA3
Gene location (Human)
Chr.	Chromosome 8 (human)
End	85,449,040 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	14,937,583 bp
RNA expression pattern
	Top expressed in
	vastus lateralis muscle; ; biceps brachii; ; thoracic diaphragm; ; gastrocnemius muscle; ; triceps brachii muscle; ; body of tongue; ; deltoid muscle; ; tibialis anterior muscle; ; right lung; ; gastric mucosa;
	Top expressed in
	intercostal muscle; ; subcutaneous adipose tissue; ; white adipose tissue; ; ankle; ; body of femur; ; brown adipose tissue; ; sternocleidomastoid muscle; ; vastus lateralis muscle; ; triceps brachii muscle; ; left lobe of liver;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	carbonate dehydratase activity; phosphatase activity; zinc ion binding; nickel cation binding; metal ion binding; lyase activity; carbonic anhydrase;
Cellular component	cytoplasm; cytosol;
Biological process	bicarbonate transport; response to ethanol; response to oxidative stress; dephosphorylation; response to bacterium;
	Sources:Amigo / QuickGO
Orthologs
	761
	12350
	ENSG00000164879
	ENSMUSG00000027559
	P07451
	P16015
	NM_005181
	NM_007606
	NP_005172
	NP_031632
	Wikidata
View/Edit Human	View/Edit Mouse

Carbonic anhydrase 3 is an enzyme that in humans is encoded by the CA3 gene.

Carbonic anhydrase III (CAIII) is a member of a multigene family (at least six separate genes are known) that encode carbonic anhydrase isozymes. These carbonic anhydrases are a class of metalloenzymes that catalyze the reversible hydration of carbon dioxide and are differentially expressed in a number of cell types. The expression of the CA3 gene is strictly tissue-specific and present at high levels in skeletal muscle and much lower levels in cardiac and smooth muscle. CA3 is insufficient in muscles of Myasthenia Gravis patients. A proportion of carriers of Duchenne muscle dystrophy have a higher CA3 level than normal. Autoantibodies to CA3 have been found to be significantly higher in patients with rheumatoid arthritis, systemic lupus erythematosus, and type 1 diabetes. The gene spans 10.3 kb and contains seven exons and six introns.

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