CYP17A1

CYP17A1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3RUK, 3SWZ, 4NKV, 4NKW, 4NKX, 4NKY, 4NKZ
Identifiers
Aliases	CYP17A1, CPT7, CYP17, P450C17, S17AH, cytochrome P450 family 17 subfamily A member 1
External IDs	OMIM: 609300 MGI: 88586 HomoloGene: 73875 GeneCards: CYP17A1
EC number	1.14.14.32 1.14.14.19, 1.14.14.32
Gene location (Human)
Chr.	Chromosome 10 (human)
End	102,837,472 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	46,661,611 bp
RNA expression pattern
	Top expressed in
	right adrenal gland; ; kidney; ; right uterine tube; ; right lobe of liver; ; right coronary artery; ; left lobe of thyroid gland; ; right lobe of thyroid gland; ; canal of the cervix; ; left uterine tube; ; gastrocnemius muscle;
	Top expressed in
	Leydig cell; ; spermatocyte; ; seminiferous tubule; ; adrenal cortex; ; placenta; ; lip; ; spermatid; ; liver; ; morula; ; yolk sac;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	iron ion binding; oxygen binding; metal ion binding; steroid 17-alpha-monooxygenase activity; monooxygenase activity; heme binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; lyase activity; oxidoreductase activity; 17-alpha-hydroxyprogesterone aldolase activity;
Cellular component	endoplasmic reticulum membrane; membrane; axon; neuronal cell body; endoplasmic reticulum;
Biological process	progesterone metabolic process; androgen biosynthetic process; glucocorticoid biosynthetic process; sterol metabolic process; hormone biosynthetic process; steroid biosynthetic process; steroid metabolic process; sex differentiation;
	Sources:Amigo / QuickGO
Orthologs
	1586
	13074
	ENSG00000148795
	ENSMUSG00000003555
	P05093
	P27786
	NM_000102
	NM_007809
	NP_000093
	NP_031835
	Wikidata
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Steroid 17-alpha-hydroxylase/17,20 lyase
Steroid 17-alpha-hydroxylase/17,20 lyase
Identifiers
EC no.	1.14.14.19
CAS no.	9029-67-8
Alt. names	P450c17, CYP17A1, steroid 17-alpha-hydroxylase/17,20 lyase, CYPXVII, cytochrome P450 17A1, cytochrome p450 XVIIA1, cytochrome P450-C17, cytochrome P450, family 17, subfamily A, polypeptide 1, steroid 17-alpha-monooxygenase, cytochrome P450c17, 4.1.2.30, 17-alpha-hydroxyprogesterone aldolase, cytochrome P450, subfamily XVII (steroid 17-alpha-hydroxylase), steroid 17 alpha-hydroxylase/17,20 lyase, IPR033282
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
PMC
Search
PMC	articles
PubMed	articles
NCBI	proteins

Cytochrome P450 17A1 (steroid 17α-monooxygenase, 17α-hydroxylase, 17-alpha-hydroxylase, 17,20-lyase, 17,20-desmolase) is an enzyme of the hydroxylase type that in humans is encoded by the CYP17A1 gene on chromosome 10. It is ubiquitously expressed in many tissues and cell types, including the zona reticularis and zona fasciculata (but not zona glomerulosa) of the adrenal cortex as well as gonadal tissues. It has both 17α-hydroxylase and 17,20-lyase activities, and is a key enzyme in the steroidogenic pathway that produces progestins, mineralocorticoids, glucocorticoids, androgens, and estrogens. More specifically, the enzyme acts upon pregnenolone and progesterone to add a hydroxyl (-OH) group at carbon 17 position (C17) of the steroid D ring (the 17α-hydroxylase activity, EC 1.14.14.19), or acts upon 17α-hydroxyprogesterone and 17α-hydroxypregnenolone to split the side-chain off the steroid nucleus (the 17,20-lyase activity, EC 1.14.14.32).

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