CUL3

CUL3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2MYL, 2MYM, 4AP2, 4APF, 4EOZ, 4HXI
Identifiers
Aliases	CUL3, CUL-3, PHA2E, cullin 3, NEDAUS
External IDs	OMIM: 603136 MGI: 1347360 HomoloGene: 2661 GeneCards: CUL3
Gene location (Human)
Chr.	Chromosome 2 (human)
End	224,585,397 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	80,318,197 bp
RNA expression pattern
	Top expressed in
	sperm; ; amniotic fluid; ; Achilles tendon; ; parotid gland; ; oral cavity; ; palpebral conjunctiva; ; triceps brachii muscle; ; ganglionic eminence; ; jejunal mucosa; ; tibia;
	Top expressed in
	spermatid; ; spermatocyte; ; seminiferous tubule; ; triceps brachii muscle; ; extensor digitorum longus muscle; ; quadriceps femoris muscle; ; gastrocnemius muscle; ; sternocleidomastoid muscle; ; temporal muscle; ; tibialis anterior muscle;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	POZ domain binding; protein homodimerization activity; ubiquitin protein ligase activity; ubiquitin-protein transferase activity; protein binding; protein heterodimerization activity; ubiquitin protein ligase binding; cyclin binding; Notch binding;
Cellular component	cytoplasm; cullin-RING ubiquitin ligase complex; cytosol; Golgi apparatus; membrane; Cul3-RING ubiquitin ligase complex; nucleoplasm; polar microtubule; extracellular exosome; nucleus; Golgi membrane; cilium; SCF ubiquitin ligase complex; motile cilium; sperm flagellum; cell projection;
Biological process	embryonic cleavage; regulation of transcription by RNA polymerase II; G1 phase; negative regulation of Rho protein signal transduction; protein polyubiquitination; in utero embryonic development; negative regulation of transcription by RNA polymerase II; Wnt signaling pathway; protein monoubiquitination; stress fiber assembly; MAPK cascade; positive regulation of cytokinesis; intrinsic apoptotic signaling pathway; endoplasmic reticulum to Golgi vesicle-mediated transport; positive regulation of mitotic metaphase/anaphase transition; COPII vesicle coating; fibroblast apoptotic process; cell projection organization; gastrulation; stem cell division; protein ubiquitination; cell morphogenesis; positive regulation of cell population proliferation; mitotic cell cycle; integrin-mediated signaling pathway; mitotic metaphase plate congression; cell migration; negative regulation of canonical Wnt signaling pathway; vesicle-mediated transport; liver morphogenesis; proteasome-mediated ubiquitin-dependent protein catabolic process; trophectodermal cellular morphogenesis; ubiquitin-dependent protein catabolic process; anaphase-promoting complex-dependent catabolic process; nuclear protein quality control by the ubiquitin-proteasome system; post-translational protein modification; transport; G1/S transition of mitotic cell cycle; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein ubiquitination; protein destabilization;
	Sources:Amigo / QuickGO
Orthologs
	8452
	26554
	ENSG00000036257
	ENSMUSG00000004364
	Q13618
	Q9JLV5
	NM_001257197; NM_001257198; NM_003590
	NM_016716; NM_001313728
	NP_001244126; NP_001244127; NP_003581
	NP_001300657; NP_057925
	Wikidata
View/Edit Human	View/Edit Mouse

Cullin 3 is a protein that in humans is encoded by the CUL3 gene.

Cullin 3 protein belongs to the family of cullins which in mammals contains eight proteins (Cullin 1, Cullin 2, Cullin 3, Cullin 4A, Cullin 4B, Cullin 5, Cullin 7 and Cullin 9). Cullin proteins are an evolutionarily conserved family of proteins throughout yeast, plants and mammals.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.