CTCF

CTCF
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1X6H, 2CT1
Identifiers
Aliases	CTCF, MRD21, CCCTC-binding factor, FAP108, CFAP108
External IDs	OMIM: 604167 MGI: 109447 HomoloGene: 4786 GeneCards: CTCF
Gene location (Human)
Chr.	Chromosome 16 (human)
End	67,639,177 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	105,682,922 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; thymus; ; cerebellar vermis; ; lymph node; ; spongy bone; ; bone marrow; ; islet of Langerhans; ; bone marrow cells; ; human penis; ; thymus;
	Top expressed in
	thymus; ; saccule; ; otic placode; ; primitive streak; ; abdominal wall; ; ganglionic eminence; ; medullary collecting duct; ; renal corpuscle; ; secondary oocyte; ; spleen;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; transcription corepressor activity; DNA-binding transcription factor activity; zinc ion binding; metal ion binding; chromatin insulator sequence binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; protein binding; nucleic acid binding; DNA-binding transcription factor activity, RNA polymerase II-specific; sequence-specific DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; chromatin binding;
Cellular component	nucleoplasm; chromosome; nucleolus; chromosome, centromeric region; condensed chromosome; nucleus;
Biological process	regulation of transcription, DNA-templated; regulation of gene expression, epigenetic; regulation of centromeric sister chromatid cohesion; chromosome segregation; transcription, DNA-templated; positive regulation of transcription, DNA-templated; negative regulation of transcription, DNA-templated; protein localization to chromosome, centromeric region; negative regulation of cell population proliferation; chromatin organization; negative regulation of transcription by RNA polymerase II; positive regulation of gene expression; DNA methylation; regulation of gene expression by genetic imprinting; maintenance of DNA methylation; negative regulation of gene expression; regulation of histone methylation; regulation of histone acetylation; positive regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	10664
	13018
	ENSG00000102974
	ENSMUSG00000005698
	P49711
	Q61164
	NM_001191022; NM_006565; NM_001363916
	NM_181322; NM_001358924
	NP_001177951; NP_006556; NP_001350845
NP_851839; NP_001345853; NP_001390652; NP_001390653; NP_001390654;
	NP_001390655; NP_001390656; NP_001390657; NP_001390658; NP_001390659; NP_001390660; NP_001390661
	Wikidata
View/Edit Human	View/Edit Mouse

Transcriptional repressor CTCF also known as 11-zinc finger protein or CCCTC-binding factor is a transcription factor that in humans is encoded by the CTCF gene. CTCF is involved in many cellular processes, including transcriptional regulation, insulator activity, V(D)J recombination and regulation of chromatin architecture.

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