LUC7L3

LUC7L3
Identifiers
Aliases	LUC7L3, CRA, CREAP-1, CROP, LUC7A, OA48-18, hLuc7A, LUC7 like 3 pre-mRNA splicing factor
External IDs	OMIM: 609434 MGI: 1914934 HomoloGene: 75056 GeneCards: LUC7L3
Gene location (Human)
Chr.	Chromosome 17 (human)
End	50,756,219 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	94,212,814 bp
RNA expression pattern
	Top expressed in
	pylorus; ; sural nerve; ; endothelial cell; ; cardia; ; tibia; ; cerebellar vermis; ; seminal vesicula; ; corpus callosum; ; inferior ganglion of vagus nerve; ; visceral pleura;
	Top expressed in
	medullary collecting duct; ; Paneth cell; ; renal corpuscle; ; ciliary body; ; retinal pigment epithelium; ; fossa; ; condyle; ; primitive streak; ; saccule; ; iris;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; protein binding; mRNA binding; RNA binding;
Cellular component	U1 snRNP; U2-type prespliceosome; nucleus; nucleoplasm; nuclear speck;
Biological process	mRNA processing; mRNA splice site selection; RNA splicing;
	Sources:Amigo / QuickGO
Orthologs
	51747
	67684
	ENSG00000108848
	ENSMUSG00000020863
	O95232
	Q5SUF2
	NM_006107; NM_016424; NM_001330330
	NM_026313; NM_001361573; NM_001361574; NM_001361575
	NP_001317259; NP_006098; NP_057508
	NP_080589; NP_001348502; NP_001348503; NP_001348504
	Wikidata
View/Edit Human	View/Edit Mouse

LUC7 like 3 pre-mRNA splicing factor (LUC7L3), also known as Cisplatin resistance-associated overexpressed protein, or CROP, is a human gene.

This gene encodes a cisplatin resistance-associated overexpressed protein (CROP). The N-terminal half of the CROP contains cysteine/histidine motifs and leucine zipper-like repeats, and the C-terminal half is rich in arginine and glutamate residues (RE domain) and arginine and serine residues (RS domain). This protein localizes with a speckled pattern in the nucleus, and could be involved in the formation of splicesome via the RE and RS domains. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.

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