CPNE1

CPNE1
Identifiers
Aliases	CPNE1, COPN1, CPN1, copine 1
External IDs	OMIM: 604205 MGI: 2386621 HomoloGene: 36501 GeneCards: CPNE1
Gene location (Human)
Chr.	Chromosome 20 (human)
End	35,664,956 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	155,953,885 bp
RNA expression pattern
	Top expressed in
	canal of the cervix; ; right lobe of thyroid gland; ; anterior pituitary; ; left lobe of thyroid gland; ; right uterine tube; ; gastric mucosa; ; tibial nerve; ; stromal cell of endometrium; ; left uterine tube; ; right coronary artery;
	Top expressed in
	yolk sac; ; thymus; ; uterus; ; lung; ; white adipose tissue; ; adrenal gland; ; spleen; ; placenta; ; cerebellum; ; hypothalamus;
	More reference expression data
	n/a
Gene ontology
Molecular function	calcium ion binding; protein homodimerization activity; transporter activity; endopeptidase activity; phosphatidylserine binding; NF-kappaB binding; protein binding; calcium-dependent phospholipid binding;
Cellular component	cytoplasm; cytosol; membrane; plasma membrane; extracellular exosome; nucleus; nucleoplasm; nuclear membrane; azurophil granule membrane;
Biological process	cellular response to calcium ion; cell differentiation; positive regulation of protein kinase B signaling; regulation of transcription, DNA-templated; lipid metabolism; positive regulation of tumor necrosis factor-mediated signaling pathway; negative regulation of DNA binding; negative regulation of gene expression; transcription, DNA-templated; proteolysis; neuron projection extension; negative regulation of NIK/NF-kappaB signaling; glycerophospholipid biosynthetic process; positive regulation of neuron differentiation; vesicle-mediated transport; regulation of I-kappaB kinase/NF-kappaB signaling; neutrophil degranulation;
	Sources:Amigo / QuickGO
Orthologs
	8904
	266692
	ENSG00000214078
	ENSMUSG00000074643
	Q99829; Q5JX58
	Q8C166
NM_001198863; NM_003915; NM_152925; NM_152926; NM_152927;
	NM_152928; NM_152930; NM_152931
	NM_170588; NM_170590
NP_001185792; NP_003906; NP_690902; NP_690903; NP_690904;
	NP_690905
	NP_733467; NP_733469
	Wikidata
View/Edit Human	View/Edit Mouse

Copine-1 is a protein that in humans is encoded by the CPNE1 gene.

CPNE is a highly homologous protein first discovered in nematodes and plants. Nine CPNEs were originally discovered (CPNE1-9) and only 8 CPNEs were found in mammals (CPNE1-8). CPNE1-3 are the most widely distributed and are found in most mammalian tissues, this includes but is not limited to, the testis, kidney, brain, lung, heart, and intestine. (CPNE-1) was reported in 1998, where it was identified by isolating annexin in Paramecium.

CPNE-1 is a highly conservedCalcium-dependent membrane-binding proteins in different eukaryotes. In humans the CPNE1 gene encodes the, calcium dependant, Copine-1 protein which has an integrin A doman and two N-terminal type II C2 domains. Where the C2 domains act as calcium dependent phospholipid binding motifs and can be included in cell signaling or membrane trafficking pathways. However, the encoded protein does not contain a predicted signal sequence or transmembrane domains. CPNE-1 may also regulate molecular events at the interface of the cell membrane and cytoplasm. This protein has a broad tissue distribution and it may function in membrane trafficking. This gene and the gene for RNA binding motif protein 12 overlap at map location 20q11.21. Sequence analysis identified multiple alternatively spliced variants in the 5' UTR. All variants encode the same protein.

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