CHRNA7

CHRNA7
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	5AFK, 5AFJ, 5AFL, 2MAW, 5AFN, 5AFM, 5AFH
Identifiers
Aliases	CHRNA7, CHRNA7-2, NACHRA7, cholinergic receptor nicotinic alpha 7 subunit
External IDs	OMIM: 118511 MGI: 99779 HomoloGene: 593 GeneCards: CHRNA7
Gene location (Human)
Chr.	Chromosome 15 (human)
End	32,173,018 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	62,862,317 bp
RNA expression pattern
	Top expressed in
	oocyte; ; secondary oocyte; ; ganglionic eminence; ; jejunal mucosa; ; retinal pigment epithelium; ; prefrontal cortex; ; left lobe of thyroid gland; ; right lobe of thyroid gland; ; rectum; ; body of pancreas;
	Top expressed in
	trigeminal nerve; ; autonomic nervous system; ; superior frontal gyrus; ; sympathetic ganglion; ; paravertebral ganglia; ; tongue; ; thoracic ganglia; ; ganglionic eminence; ; cerebellar cortex; ; hippocampus proper;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein homodimerization activity; acetylcholine binding; acetylcholine-gated cation-selective channel activity; amyloid-beta binding; acetylcholine receptor activity; ion channel activity; chloride channel regulator activity; extracellular ligand-gated ion channel activity; toxic substance binding; ligand-gated ion channel activity; transmembrane signaling receptor activity; calcium channel activity; protein binding;
Cellular component	integral component of membrane; acetylcholine-gated channel complex; postsynaptic membrane; membrane; plasma membrane; synapse; cell junction; integral component of plasma membrane; neuron projection; plasma membrane raft; postsynapse;
Biological process	response to hypoxia; cognition; cellular calcium ion homeostasis; ion transport; positive regulation of angiogenesis; ion transmembrane transport; positive regulation of cell population proliferation; transport; calcium ion transport; signal transduction; synaptic transmission, cholinergic; memory; negative regulation of tumor necrosis factor production; response to nicotine; regulation of postsynaptic membrane potential; excitatory postsynaptic potential; positive regulation of protein phosphorylation; chemical synaptic transmission; learning or memory; short-term memory; regulation of membrane potential; synapse organization; nervous system process; sensory processing; positive regulation of ERK1 and ERK2 cascade; calcium ion transmembrane transport; acetylcholine receptor signaling pathway; dendritic spine organization; modulation of excitatory postsynaptic potential; dendrite arborization; positive regulation of long-term synaptic potentiation; regulation of neuron death; positive regulation of amyloid-beta formation; negative regulation of amyloid-beta formation; regulation of amyloid precursor protein catabolic process; response to amyloid-beta; response to acetylcholine; regulation of amyloid fibril formation; positive regulation of CoA-transferase activity; positive regulation of excitatory postsynaptic potential;
	Sources:Amigo / QuickGO
Orthologs
	1139
	11441
	ENSG00000274542; ENSG00000175344; ENSG00000282088
	ENSMUSG00000030525
	P36544
	P49582
	NM_000746; NM_001190455
	NM_007390
	NP_000737; NP_001177384
	NP_031416
	Wikidata
View/Edit Human	View/Edit Mouse

Neuronal acetylcholine receptor subunit alpha-7, also known as nAChRα7, is a protein that in humans is encoded by the CHRNA7 gene. The protein encoded by this gene is a subunit of certain nicotinic acetylcholine receptors (nAchR).

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