CHRNA3

CHRNA3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4ZK4
Identifiers
Aliases	CHRNA3, LNCR2, NACHRA3, PAOD2, cholinergic receptor nicotinic alpha 3 subunit, BAIPRCK
External IDs	OMIM: 118503 MGI: 87887 HomoloGene: 591 GeneCards: CHRNA3
Gene location (Human)
Chr.	Chromosome 15 (human)
End	78,621,295 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	54,933,846 bp
RNA expression pattern
	Top expressed in
	retinal pigment epithelium; ; thymus; ; secondary oocyte; ; appendix; ; rectum; ; transverse colon; ; ganglionic eminence; ; smooth muscle tissue; ; right adrenal gland; ; cerebellar vermis;
	Top expressed in
	habenula; ; superior cervical ganglion; ; pineal gland; ; neural tube; ; adrenal gland; ; stellate ganglion; ; trigeminal ganglion; ; Hindgut; ; trigeminal nerve; ; mesencephalon;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	ion channel activity; ligand-gated ion channel activity; extracellular ligand-gated ion channel activity; acetylcholine binding; acetylcholine receptor activity; transmembrane signaling receptor activity; protein binding; acetylcholine-gated cation-selective channel activity;
Cellular component	integral component of membrane; postsynaptic membrane; membrane; plasma membrane; synapse; cell junction; dendrite; acetylcholine-gated channel complex; postsynaptic density; neuronal cell body; integral component of plasma membrane; neuron projection; plasma membrane raft;
Biological process	locomotory behavior; regulation of smooth muscle contraction; regulation of membrane potential; regulation of acetylcholine secretion, neurotransmission; synaptic transmission, cholinergic; ion transport; cation transmembrane transport; nervous system development; behavioral response to nicotine; regulation of dendrite morphogenesis; synaptic transmission involved in micturition; excitatory postsynaptic potential; transport; activation of transmembrane receptor protein tyrosine kinase activity; signal transduction; ion transmembrane transport; chemical synaptic transmission; neuromuscular synaptic transmission; response to nicotine; nervous system process; acetylcholine receptor signaling pathway; response to acetylcholine;
	Sources:Amigo / QuickGO
Orthologs
	1136
	110834
	ENSG00000080644
	ENSMUSG00000032303
	P32297
	Q8R4G9
	NM_000743; NM_001166694
	NM_145129
	NP_000734; NP_001160166
	NP_660111
	Wikidata
View/Edit Human	View/Edit Mouse

Neuronal acetylcholine receptor subunit alpha-3, also known as nAChRα3, is a protein that in humans is encoded by the CHRNA3 gene. The protein encoded by this gene is a subunit of certain nicotinic acetylcholine receptors (nAchR). Research with mecamylamine in animals has implicated alpha-3-containing nAChRs in the abusive and addictive properties of ethanol.

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