Centrin 1

CETN1
Identifiers
Aliases	CETN1, CEN1, CETN, centrin 1
External IDs	OMIM: 603187 MGI: 1347086 HomoloGene: 105668 GeneCards: CETN1
Gene location (Human)
Chr.	Chromosome 18 (human)
End	582,114 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	9,619,478 bp
RNA expression pattern
	Top expressed in
	sperm; ; human musculoskeletal system; ; muscular system; ; muscle; ; muscle; ; gland; ; human thorax; ; male reproductive gland; ; integument; ; prostate;
	Top expressed in
	spermatid; ; spermatocyte; ; seminiferous tubule; ; motor neuron; ; submandibular gland; ; spinal ganglia; ; carotid body; ; trachea; ; triceps brachii muscle; ; blastocyst;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	microtubule binding; calcium ion binding; G-protein beta/gamma-subunit complex binding; heterotrimeric G-protein binding; protein binding; metal ion binding;
Cellular component	cytoplasm; microtubule organizing center; centrosome; spindle pole; cytoskeleton; photoreceptor connecting cilium; centriole; nucleus;
Biological process	cell cycle; cellular response to heat; cell division; mitotic cytokinesis; centriole replication; regulation of centrosome duplication; calcium-mediated signaling; regulation of cytokinesis; microtubule cytoskeleton organization; nucleotide-excision repair; mitotic cell cycle;
	Sources:Amigo / QuickGO
Orthologs
	1068
	26369
	ENSG00000177143
	ENSMUSG00000050996
	Q12798
	P41209
	NM_004066
	NM_007593
	NP_004057
	NP_031619
	Wikidata
View/Edit Human	View/Edit Mouse

Centrin-1 is a protein that in humans is encoded by the CETN1 gene. It belongs to the centrin family of proteins.

The protein encoded by this gene plays important roles in the determination of centrosome position and segregation, and in the process of microtubule severing. This encoded protein is localized to the centrosome of interphase cells, and redistributes to the region of the spindle poles during mitosis, reflecting the dynamic behavior of the centrosome during the cell cycle.

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