CDKL5

CDKL5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4BGQ
Identifiers
Aliases	CDKL5, EIEE2, ISSX, STK9, CFAP247, cyclin dependent kinase like 5, DEE2
External IDs	OMIM: 300203 MGI: 1278336 HomoloGene: 55719 GeneCards: CDKL5
Gene location (Human)
Chr.	X chromosome (human)
End	18,653,629 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	159,777,700 bp
RNA expression pattern
	Top expressed in
	frontal pole; ; Brodmann area 23; ; middle temporal gyrus; ; endothelial cell; ; palpebral conjunctiva; ; superior frontal gyrus; ; entorhinal cortex; ; visceral pleura; ; postcentral gyrus; ; amniotic fluid;
	Top expressed in
	medial dorsal nucleus; ; medial geniculate nucleus; ; primary motor cortex; ; lateral geniculate nucleus; ; cingulate gyrus; ; piriform cortex; ; Region I of hippocampus proper; ; prefrontal cortex; ; olfactory tubercle; ; temporal lobe;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; protein kinase activity; nucleotide binding; kinase activity; protein serine/threonine kinase activity; ATP binding; cyclin-dependent protein serine/threonine kinase activity;
Cellular component	dendritic growth cone; nucleoplasm; ruffle membrane; nucleus; cytosol; dendrite cytoplasm; synapse; perinuclear region of cytoplasm; centrosome; ciliary basal body; ciliary tip; cytoplasm; microtubule organizing center; cytoskeleton; cell projection; glutamatergic synapse; postsynaptic density, intracellular component;
Biological process	phosphorylation; neuron migration; protein phosphorylation; positive regulation of GTPase activity; positive regulation of dendrite morphogenesis; protein autophosphorylation; positive regulation of axon extension; regulation of dendrite development; positive regulation of dendritic spine development; regulation of cilium assembly; regulation of cell cycle; regulation of postsynapse organization;
	Sources:Amigo / QuickGO
Orthologs
	6792
	382253
	ENSG00000008086
	ENSMUSG00000031292
	O76039
	Q3UTQ8
	NM_001037343; NM_003159; NM_001323289
	NM_001024624
	NP_001032420; NP_001310218; NP_003150
	NP_001019795
	Wikidata
View/Edit Human	View/Edit Mouse

CDKL5 is a gene that provides instructions for making a protein called cyclin-dependent kinase-like 5 also known as serine/threonine kinase 9 (STK9) that is essential for normal brain development. Mutations in the gene can cause deficiencies in the protein. The gene regulates neuronal morphology through cytoplasmic signaling and controlling gene expression. The CDKL5 protein acts as a kinase, which is an enzyme that changes the activity of other proteins by adding a cluster of oxygen and phosphorus atoms (a phosphate group) at specific positions. Researchers are currently working to determine which proteins are targeted by the CDKL5 protein.

The CDKL5 protein acts as a kinase, which is an enzyme that modulates the activity of other proteins by adding a phosphate group to specific positions. The CDKL5 protein regulates neuronal morphology through cytoplasmic signaling and by controlling gene expression, playing a crucial role in the development and maintenance of the nervous system.

Studies have shown that the CDKL5 protein interacts with various signaling pathways and plays a role in controlling neurotransmitter release, synaptic plasticity, and cell survival. The CDKL5 protein has also been shown to regulate the activity of genes involved in neuronal development and the formation of synaptic connections.

Researchers are actively working to better understand the role of the CDKL5 protein in brain development and the underlying mechanisms of CDKL5 disorders. Further studies are needed to determine which proteins are targeted by the CDKL5 protein, as well as to develop effective treatments for individuals affected by CDKL5 disorders.

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