CDK13

CDK13
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	5EFQ
Identifiers
Aliases	CDK13, CDC2L, CDC2L5, CHED, hcyclin-dependent kinase 13, cyclin dependent kinase 13, CHDFIDD
External IDs	OMIM: 603309 MGI: 1916812 HomoloGene: 135707 GeneCards: CDK13
Gene location (Human)
Chr.	Chromosome 7 (human)
End	40,099,580 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	17,979,682 bp
RNA expression pattern
	Top expressed in
	renal medulla; ; visceral pleura; ; pylorus; ; nipple; ; cardia; ; endothelial cell; ; ventral tegmental area; ; inferior ganglion of vagus nerve; ; parietal pleura; ; external globus pallidus;
	Top expressed in
	spermatocyte; ; hand; ; spermatid; ; thymus; ; spleen; ; lymph node; ; secondary oocyte; ; otolith organ; ; foot; ; ganglionic eminence;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; protein kinase activity; nucleotide binding; kinase activity; protein serine/threonine kinase activity; protein binding; RNA polymerase II CTD heptapeptide repeat kinase activity; ATP binding; cyclin binding; cyclin-dependent protein serine/threonine kinase activity; transcription factor binding; protein kinase binding; RNA binding;
Cellular component	Golgi apparatus; nuclear speck; nuclear cyclin-dependent protein kinase holoenzyme complex; cyclin K-CDK13 complex; nucleus; extracellular region; extracellular space; nucleoplasm; chromosome; cytosol; cyclin/CDK positive transcription elongation factor complex; ficolin-1-rich granule lumen; cyclin-dependent protein kinase holoenzyme complex;
Biological process	hemopoiesis; phosphorylation of RNA polymerase II C-terminal domain; phosphorylation; mRNA processing; multicellular organism development; protein phosphorylation; RNA splicing; positive regulation of cell population proliferation; viral process; alternative mRNA splicing, via spliceosome; regulation of mitotic nuclear division; transcription elongation from RNA polymerase II promoter; neutrophil degranulation; positive regulation of transcription by RNA polymerase II; negative regulation of stem cell differentiation; positive regulation of transcription elongation from RNA polymerase II promoter;
	Sources:Amigo / QuickGO
Orthologs
	8621
	69562
	ENSG00000065883
	ENSMUSG00000041297
	Q14004
	Q69ZA1
	NM_003718; NM_031267
	NM_001081058; NM_027118
	NP_003709; NP_112557
	NP_001074527; NP_081394
	Wikidata
View/Edit Human	View/Edit Mouse

Cyclin dependent kinase 13 is an enzyme that in humans is encoded by the CDK13 gene.

The protein encoded by this gene is a member of the cyclin-dependent serine/threonine protein kinase family. Members of this family are well known for their essential roles as master switches in cell cycle control. Some of the cell cycle control kinases are able to phosphorylate proteins that are important for cell differentiation and apoptosis, thus provide connections between cell proliferation, differentiation, and apoptosis. Proteins of this family may also be involved in non-cell cycle-related functions, such as neurocytoskeleton dynamics. The exact function of this protein has not yet been determined. It has unusually large N- and C-termini and is ubiquitously expressed in many tissues. Two alternatively spliced variants are described.

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