Cadherin-1

CDH1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1O6S, 2O72, 2OMT, 2OMU, 2OMV, 2OMX, 2OMY, 2OMZ, 3FF7, 3FF8, 3L6X, 3L6Y, 4ZT1, 4ZTE
Identifiers
Aliases	CDH1, Arc-1, CD324, CDHE, ECAD, LCAM, UVO, cadherin 1, BCDS1, E-cadherin, uvomorulin
External IDs	OMIM: 192090 MGI: 88354 HomoloGene: 20917 GeneCards: CDH1
Gene location (Human)
Chr.	Chromosome 16 (human)
End	68,835,537 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	107,396,878 bp
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; palpebral conjunctiva; ; bronchial epithelial cell; ; duodenum; ; vulva; ; human penis; ; hair follicle; ; oral cavity; ; islet of Langerhans; ; rectum;
	Top expressed in
	epithelium of stomach; ; left colon; ; stria vascularis; ; mucous cell of stomach; ; submandibular gland; ; pyloric antrum; ; left lung lobe; ; ileum; ; conjunctival fornix; ; molar;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; protein binding; ankyrin binding; gamma-catenin binding; beta-catenin binding; GTPase activating protein binding; metal ion binding; cell adhesion molecule binding; cadherin binding; identical protein binding; cytoskeletal protein binding; protein homodimerization activity;
Cellular component	apical junction complex; trans-Golgi network; extracellular region; perinuclear region of cytoplasm; cortical actin cytoskeleton; Golgi apparatus; lamellipodium; cytoplasmic side of plasma membrane; endosome; lateral plasma membrane; catenin complex; actin cytoskeleton; flotillin complex; membrane; extracellular exosome; integral component of membrane; cell junction; cytoplasm; plasma membrane; cell surface; postsynapse; glutamatergic synapse;
Biological process	negative regulation of cell-cell adhesion; positive regulation of transcription, DNA-templated; cellular response to lithium ion; cell adhesion; extracellular matrix organization; cellular response to indole-3-methanol; extracellular matrix disassembly; synapse assembly; pituitary gland development; response to toxic substance; response to organic substance; neuron projection development; adherens junction organization; homophilic cell adhesion via plasma membrane adhesion molecules; entry of bacterium into host cell; protein localization to plasma membrane; cell-cell adhesion; cell morphogenesis; cell-cell junction assembly; regulation of gene expression; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; negative regulation of cell migration; positive regulation of protein import into nucleus; cell-cell adhesion mediated by cadherin; regulation of protein catabolic process at postsynapse, modulating synaptic transmission;
	Sources:Amigo / QuickGO
Orthologs
	999
	12550
	ENSG00000039068
	ENSMUSG00000000303
	P12830
	P09803
	NM_004360; NM_001317184; NM_001317185; NM_001317186
	NM_009864
	NP_001304113; NP_001304114; NP_001304115; NP_004351
	NP_033994
	Wikidata
View/Edit Human	View/Edit Mouse

Cadherin-1 or Epithelial cadherin (E-cadherin), (not to be confused with the APC/C activator protein CDH1) is a protein that in humans is encoded by the CDH1 gene. Mutations are correlated with gastric, breast, colorectal, thyroid, and ovarian cancers. CDH1 has also been designated as CD324 (cluster of differentiation 324). It is a tumor suppressor gene.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.