Cell division cycle 7-related protein kinase

CDC7
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4F99, 4F9A, 4F9B, 4F9C
Identifiers
Aliases	CDC7, CDC7L1, HsHsk1, hucell division cycle 7
External IDs	OMIM: 603311 MGI: 1309511 HomoloGene: 31166 GeneCards: CDC7
Gene location (Human)
Chr.	Chromosome 1 (human)
End	91,525,764 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	107,132,298 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; endothelial cell; ; embryo; ; ganglionic eminence; ; cerebellar hemisphere; ; testicle; ; spleen; ; bone marrow; ; lymph node; ; Brodmann area 23;
	Top expressed in
	otic placode; ; saccule; ; medullary collecting duct; ; primitive streak; ; Paneth cell; ; condyle; ; spermatocyte; ; vas deferens; ; fossa; ; abdominal wall;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; protein kinase activity; nucleotide binding; metal ion binding; kinase activity; protein serine/threonine kinase activity; protein binding; ATP binding;
Cellular component	cytoplasm; nucleoplasm; intercellular bridge; nucleus; mitotic spindle;
Biological process	cell cycle phase transition; phosphorylation; double-strand break repair via break-induced replication; positive regulation of nuclear cell cycle DNA replication; cell division; DNA replication; protein phosphorylation; DNA replication initiation; peptidyl-serine phosphorylation; positive regulation of cell population proliferation; phagocytosis; positive regulation of G2/M transition of mitotic cell cycle; cell cycle; regulation of cell shape; negative regulation of G0 to G1 transition; G1/S transition of mitotic cell cycle; peptidyl-threonine phosphorylation;
	Sources:Amigo / QuickGO
Orthologs
	8317
	12545
	ENSG00000097046
	ENSMUSG00000029283
	O00311
	Q9Z0H0
	NM_001134419; NM_001134420; NM_003503
	NM_001271566; NM_001271567; NM_001271568; NM_009863
	NP_001127891; NP_001127892; NP_003494
	NP_001258495; NP_001258496; NP_001258497; NP_033993
	Wikidata
View/Edit Human	View/Edit Mouse

Cell division cycle 7-related protein kinase is an enzyme that in humans is encoded by the CDC7 gene. The Cdc7 kinase is involved in regulation of the cell cycle at the point of chromosomal DNA replication. The gene CDC7 appears to be conserved throughout eukaryotic evolution; this means that most eukaryotic cells have the Cdc7 kinase protein.

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