CD19

CD19
Identifiers
Aliases	CD19, B4, CVID3, CD19 molecule
External IDs	OMIM: 107265 MGI: 88319 HomoloGene: 1341 GeneCards: CD19
Gene location (Human)
Chr.	Chromosome 16 (human)
End	28,939,342 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	126,014,061 bp
RNA expression pattern
	Top expressed in
	spleen; ; lymph node; ; appendix; ; bone marrow cells; ; blood; ; thymus; ; superficial temporal artery; ; spongy bone; ; rectum; ; gallbladder;
	Top expressed in
	spleen; ; blood; ; subcutaneous adipose tissue; ; bone marrow; ; thymus; ; white adipose tissue; ; morula; ; body of femur; ; lung; ; colon;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; phosphatidylinositol-4,5-bisphosphate 3-kinase activity;
Cellular component	integral component of membrane; plasma membrane; integral component of plasma membrane; extracellular exosome; membrane; external side of plasma membrane; protein-containing complex; membrane raft;
Biological process	cellular defense response; cell surface receptor signaling pathway; regulation of immune response; positive regulation of release of sequestered calcium ion into cytosol; phosphatidylinositol phosphate biosynthetic process; B cell receptor signaling pathway; regulation of complement activation; positive regulation of protein kinase B signaling; B-1 B cell differentiation; B cell proliferation involved in immune response; immunoglobulin mediated immune response; B cell mediated immunity; positive regulation of phosphatidylinositol 3-kinase activity; antigen receptor-mediated signaling pathway; regulation of B cell receptor signaling pathway; regulation of B cell activation; adaptive immune response; immune system process;
	Sources:Amigo / QuickGO
Orthologs
	930
	12478
	ENSG00000177455
	ENSMUSG00000030724
	P15391
	P25918
	NM_001178098; NM_001770; NM_001385732
	NM_009844; NM_001357091
	NP_001171569; NP_001761
	NP_033974; NP_001344020
	Wikidata
View/Edit Human	View/Edit Mouse

B-lymphocyte antigen CD19, also known as CD19 molecule (Cluster of Differentiation 19), B-Lymphocyte Surface Antigen B4, T-Cell Surface Antigen Leu-12 and CVID3 is a transmembrane protein that in humans is encoded by the gene CD19. In humans, CD19 is expressed in all B lineage cells. Contrary to some early doubts, human plasma cells do express CD19, as confirmed by others. CD19 plays two major roles in human B cells: on the one hand, it acts as an adaptor protein to recruit cytoplasmic signaling proteins to the membrane; on the other, it works within the CD19/CD21 complex to decrease the threshold for B cell receptor signaling pathways. Due to its presence on all B cells, it is a biomarker for B lymphocyte development, lymphoma diagnosis and can be utilized as a target for leukemia immunotherapies.

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