CAD protein

CAD protein (carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase) is a trifunctional multi-domain enzyme involved in the first three steps of pyrimidine biosynthesis. De-novo synthesis starts with cytosolic carbamoylphosphate synthetase II which uses glutamine, carbon dioxide and ATP. This enzyme is inhibited by uridine triphosphate (feedback inhibition).

CAD
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCAD, CDG1Z, carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase, GATD4, EIEE50, DEE50
External IDsOMIM: 114010 MGI: 1916969 HomoloGene: 1412 GeneCards: CAD
Orthologs
SpeciesHumanMouse
Entrez

790

69719

Ensembl

ENSG00000084774

ENSMUSG00000013629

UniProt

P27708

B2RQC6

RefSeq (mRNA)

NM_001306079
NM_004341

NM_001289522
NM_001289523
NM_023525

RefSeq (protein)

NP_001293008
NP_004332

NP_001276451
NP_001276452
NP_076014
NP_001390328
NP_001390329

Location (UCSC)Chr 2: 27.22 – 27.24 MbChr 5: 31.21 – 31.24 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

In 2015, the first observed pathological mutations of CAD were found in a four-year-old boy.

CAD protein has been observed in the mid-piece of mammalian spermatozoa, among the mitochondria.

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