Butyrylcholinesterase

BCHE
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1P0P, 4AXB, 4B0P, 2XQG, 1XLV, 2WIK, 2WIL, 1P0Q, 1XLU, 4BDS, 2XQF, 2PM8, 2XQK, 4AQD, 4BBZ, 2WID, 2XMB, 1XLW, 2XMC, 4TPK, 2XMG, 2XMD, 3DKK, 3O9M, 2WSL, 2WIJ, 1P0I, 2WIG, 2XQJ, 3DJY, 1P0M, 4B0O, 2XQI, 2Y1K, 4XII, 2WIF, 2J4C
Identifiers
Aliases	BCHE, CHE1, CHE2, E1, butyrylcholinesterase, BCHED
External IDs	OMIM: 177400 MGI: 894278 HomoloGene: 20065 GeneCards: BCHE
Gene location (Human)
Chr.	Chromosome 3 (human)
End	165,837,462 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	73,615,748 bp
RNA expression pattern
	Top expressed in
	parietal pleura; ; right lobe of liver; ; germinal epithelium; ; left uterine tube; ; pericardium; ; seminal vesicula; ; visceral pleura; ; rectum; ; smooth muscle tissue; ; canal of the cervix;
	Top expressed in
	duodenum; ; left lobe of liver; ; ascending aorta; ; white adipose tissue; ; atrium; ; brown adipose tissue; ; intercostal muscle; ; epithelium of stomach; ; jejunum; ; aortic valve;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	carboxylic ester hydrolase activity; amyloid-beta binding; cholinesterase activity; choline binding; catalytic activity; identical protein binding; acetylcholinesterase activity; enzyme binding; hydrolase activity; hydrolase activity, acting on ester bonds;
Cellular component	endoplasmic reticulum lumen; blood microparticle; membrane; extracellular region; endoplasmic reticulum; nuclear envelope lumen; extracellular space;
Biological process	choline metabolic process; response to nutrient; neuroblast differentiation; response to glucocorticoid; negative regulation of synaptic transmission; learning; cocaine metabolic process; response to alkaloid; response to folic acid; negative regulation of cell population proliferation;
	Sources:Amigo / QuickGO
Orthologs
	590
	12038
	ENSG00000114200
	ENSMUSG00000027792
	P06276
	Q03311
	NM_000055
	NM_009738
	NP_000046
	NP_033868
	Wikidata
View/Edit Human	View/Edit Mouse

Butyrylcholinesterase (HGNC symbol BCHE; EC 3.1.1.8), also known as BChE, BuChE, BuChase, pseudocholinesterase, or plasma (cholin)esterase, is a nonspecific cholinesterase enzyme that hydrolyses many different choline-based esters. In humans, it is made in the liver, found mainly in blood plasma, and encoded by the BCHE gene.

It is very similar to the neuronal acetylcholinesterase, which is also known as RBC or erythrocyte cholinesterase. The term "serum cholinesterase" is generally used in reference to a clinical test that reflects levels of both of these enzymes in the blood. Assay of butyrylcholinesterase activity in plasma can be used as a liver function test as both hypercholinesterasemia and hypocholinesterasemia indicate pathological processes. The half-life of BCHE is approximately 10 to 14 days.

Butyrylcholine is a synthetic compound that does not occur in the body naturally. It is used as a tool to distinguish between acetylcholinesterase and butyrylcholinesterase.

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