Bruton's tyrosine kinase

BTK
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1AWW, 1AWX, 1B55, 1BTK, 1BWN, 1K2P, 1QLY, 2GE9, 2Z0P, 3GEN, 3K54, 3OCS, 3OCT, 3P08, 3PIX, 3PIY, 3PIZ, 3PJ1, 3PJ2, 3PJ3, 4NWM, 4OT5, 4OT6, 4OTF, 4OTQ, 4OTR, 4RFY, 4RFZ, 4RG0, 4YHF, 4Z3V, 4ZLY, 4ZLZ, 5BPY, 5BQ0, 5FBN, 4RX5, 5FBO
Identifiers
Aliases	BTK, AGMX1, AT, ATK, BPK, IMD1, PSCTK1, XLA, Bruton tyrosine kinase, IGHD3
External IDs	OMIM: 300300 MGI: 88216 HomoloGene: 30953 GeneCards: BTK
Gene location (Human)
Chr.	X chromosome (human)
End	101,390,796 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	133,484,319 bp
RNA expression pattern
	Top expressed in
	monocyte; ; spleen; ; bone marrow cells; ; lymph node; ; blood; ; appendix; ; right lung; ; upper lobe of left lung; ; rectum; ; gallbladder;
	Top expressed in
	spleen; ; blood; ; bone marrow; ; secondary oocyte; ; right lobe of liver; ; pharynx; ; body of femur; ; morula; ; subcutaneous adipose tissue; ; yolk sac;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	metal ion binding; nucleotide binding; lipid binding; signaling receptor binding; identical protein binding; protein kinase activity; transferase activity; kinase activity; phosphatidylinositol-3,4,5-trisphosphate binding; non-membrane spanning protein tyrosine kinase activity; ATP binding; protein binding; protein tyrosine kinase activity;
Cellular component	cytoplasm; nucleus; membrane; membrane raft; extrinsic component of cytoplasmic side of plasma membrane; cytoplasmic vesicle; cytosol; plasma membrane; perinuclear region of cytoplasm; mast cell granule;
Biological process	transmembrane receptor protein tyrosine kinase signaling pathway; mesoderm development; intracellular signal transduction; peptidyl-tyrosine autophosphorylation; B cell activation; positive regulation of NF-kappaB transcription factor activity; transcription, DNA-templated; positive regulation of B cell differentiation; B cell receptor signaling pathway; Fc-epsilon receptor signaling pathway; regulation of cell population proliferation; adaptive immune response; apoptotic process; peptidyl-tyrosine phosphorylation; protein phosphorylation; negative regulation of cytokine production; MyD88-dependent toll-like receptor signaling pathway; apoptotic signaling pathway; calcium-mediated signaling; I-kappaB kinase/NF-kappaB signaling; innate immune response; regulation of transcription, DNA-templated; cell maturation; immune system process; regulation of B cell cytokine production; regulation of B cell apoptotic process; phosphorylation; histamine secretion by mast cell; response to organic substance; positive regulation of type III hypersensitivity; protein autophosphorylation; cellular response to reactive oxygen species; cellular response to molecule of fungal origin; positive regulation of type I hypersensitivity; B cell affinity maturation; negative regulation of B cell proliferation; cellular response to interleukin-7; T cell receptor signaling pathway; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	695
	12229
	ENSG00000010671
	ENSMUSG00000031264
	Q06187
	P35991
	NM_001287345; NM_000061; NM_001287344
	NM_013482
	NP_000052; NP_001274273; NP_001274274
	NP_038510
	Wikidata
View/Edit Human	View/Edit Mouse

Bruton's tyrosine kinase (abbreviated Btk or BTK), also known as tyrosine-protein kinase BTK, is a tyrosine kinase that is encoded by the BTK gene in humans. BTK plays a crucial role in B cell development.

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