Blood vessel epicardial substance

BVES
Identifiers
Aliases	BVES, HPOP1, POPDC1, LGMD2X, blood vessel epicardial substance, CARICK, LGMDR25
External IDs	OMIM: 604577 MGI: 1346013 HomoloGene: 48497 GeneCards: BVES
Gene location (Human)
Chr.	Chromosome 6 (human)
End	105,137,157 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	45,248,575 bp
RNA expression pattern
	Top expressed in
	tibialis anterior muscle; ; deltoid muscle; ; vastus lateralis muscle; ; biceps brachii; ; right ventricle; ; gastrocnemius muscle; ; sperm; ; secondary oocyte; ; smooth muscle tissue; ; stromal cell of endometrium;
	Top expressed in
	interventricular septum; ; ventricle; ; atrium; ; atrioventricular valve; ; right atrium; ; left ventricle; ; temporal muscle; ; myocardium of ventricle; ; gastrocnemius muscle; ; extraocular muscle;
	More reference expression data
	n/a
Gene ontology
Molecular function	cAMP binding; structural molecule activity; protein binding; nucleotide binding;
Cellular component	integral component of membrane; lateral plasma membrane; membrane; bicellular tight junction; sarcolemma; caveola; cell junction; plasma membrane; cell projection membrane;
Biological process	muscle organ development; epithelial cell-cell adhesion; multicellular organism development; heart development; cell adhesion; skeletal muscle tissue development; positive regulation of receptor recycling; regulation of heart rate; hematopoietic progenitor cell differentiation; response to ischemia; regulation of cell shape; vesicle-mediated transport; substrate adhesion-dependent cell spreading; positive regulation of locomotion; regulation of membrane potential; regulation of GTPase activity; vesicle docking; sinoatrial node cell development; cell migration involved in heart development; regulation of endocytic recycling; striated muscle cell differentiation;
	Sources:Amigo / QuickGO
Orthologs
	11149
	23828
	ENSG00000112276
	ENSMUSG00000071317
	Q8NE79
	Q9ES83
	NM_001199563; NM_007073; NM_147147
	NM_024285
	NP_001186492; NP_009004; NP_671488
	NP_077247
	Wikidata
View/Edit Human	View/Edit Mouse

Blood vessel epicardial substance (BVES) also known as popeye domain-containing protein 1 (POPDC1) is a protein that is encoded by the BVES gene in humans.

Bves is a highly conserved, transmembrane protein that is involved in cell adhesion, cell motility, and most recently has been shown to play a role in vesicular transport. Bves is found in a wide variety of organisms (from flies to humans) and is a member of the evolutionarily conserved Popdc family of proteins. Although the precise molecular function of Bves is unknown, disruption of this protein results in developmental defects and impaired cellular processes fundamental to living organisms.

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