Biliverdin reductase
Biliverdin reductase (BVR) is an enzyme (EC 1.3.1.24) found in all tissues under normal conditions, but especially in reticulo-macrophages of the liver and spleen. BVR facilitates the conversion of biliverdin to bilirubin via the reduction of a double bond between the second and third pyrrole ring into a single bond.
| biliverdin reductase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.3.1.24 | ||||||||
| CAS no. | 9074-10-6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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| biliverdin reductase A | |||||||
|---|---|---|---|---|---|---|---|
Crystallographic structure of human biliverdin reductase A based on the PDB: 2H63 coordinates. The enzyme is displayed as a rainbow colored cartoon (N-terminus = blue, C-terminus = red) while the NADP cofactor is displayed as space-filling model (carbon = white, oxygen = red, nitrogen = blue, phosphorus = orange). | |||||||
| Identifiers | |||||||
| Symbol | BLVRA | ||||||
| Alt. symbols | BLVR | ||||||
| NCBI gene | 644 | ||||||
| HGNC | 1062 | ||||||
| OMIM | 109750 | ||||||
| RefSeq | NM_000712 | ||||||
| UniProt | P53004 | ||||||
| Other data | |||||||
| EC number | 1.3.1.24 | ||||||
| Locus | Chr. 7 p14-cen | ||||||
| |||||||
| biliverdin reductase B | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | BLVRB | ||||||
| Alt. symbols | FLR | ||||||
| NCBI gene | 645 | ||||||
| HGNC | 1063 | ||||||
| OMIM | 600941 | ||||||
| RefSeq | NM_000713 | ||||||
| UniProt | P30043 | ||||||
| Other data | |||||||
| EC number | 1.3.1.24 | ||||||
| Locus | Chr. 19 q13.1-13.2 | ||||||
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| Biliverdin reductase, catalytic | |||||||||
|---|---|---|---|---|---|---|---|---|---|
crystal structure of a biliverdin reductase enzyme-cofactor complex | |||||||||
| Identifiers | |||||||||
| Symbol | Biliv-reduc_cat | ||||||||
| Pfam | PF09166 | ||||||||
| InterPro | IPR015249 | ||||||||
| SCOP2 | 1lc0 / SCOPe / SUPFAM | ||||||||
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There are two isozymes in humans, each encoded by its own gene, biliverdin reductase A (BLVRA) and biliverdin reductase B (BLVRB).
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