G protein-coupled receptor kinase 2

GRK2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4PNK, 1BAK, 3CIK, 3KRW, 3KRX, 3V5W, 4MK0, 5HE1
Identifiers
Aliases	GRK2, BARK1, BETA-ARK1, ADRBK1, G protein-coupled receptor kinase 2
External IDs	OMIM: 109635 MGI: 87940 HomoloGene: 1223 GeneCards: GRK2
Gene location (Human)
Chr.	Chromosome 11 (human)
End	67,286,556 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	4,356,250 bp
RNA expression pattern
	Top expressed in
	monocyte; ; spleen; ; skin of abdomen; ; upper lobe of left lung; ; right lung; ; gallbladder; ; ganglionic eminence; ; right uterine tube; ; gastric mucosa; ; left uterine tube;
	Top expressed in
	superior frontal gyrus; ; thymus; ; esophagus; ; cerebellar cortex; ; lymph node; ; lip; ; spleen; ; blood; ; prefrontal cortex; ; right ventricle;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; Edg-2 lysophosphatidic acid receptor binding; protein kinase activity; nucleotide binding; G protein-coupled receptor kinase activity; kinase activity; protein serine/threonine kinase activity; protein binding; alpha-2A adrenergic receptor binding; ATP binding; beta-adrenergic receptor kinase activity;
Cellular component	cytoplasm; cytosol; membrane; plasma membrane; cilium;
Biological process	G protein-coupled acetylcholine receptor signaling pathway; cardiac muscle contraction; phosphorylation; regulation of the force of heart contraction; viral genome replication; negative regulation of striated muscle contraction; positive regulation of catecholamine secretion; receptor internalization; tachykinin receptor signaling pathway; protein phosphorylation; heart development; peptidyl-serine phosphorylation; viral entry into host cell; desensitization of G protein-coupled receptor signaling pathway; peptidyl-threonine phosphorylation; negative regulation of the force of heart contraction by chemical signal; signal transduction; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	156
	110355
	ENSG00000173020
	ENSMUSG00000024858
	P25098
	Q99MK8
	NM_001619
	NM_001290818; NM_130863
	NP_001610
	NP_001277747; NP_570933
	Wikidata
View/Edit Human	View/Edit Mouse

G-protein-coupled receptor kinase 2 (GRK2) is an enzyme that in humans is encoded by the ADRBK1 gene. GRK2 was initially called Beta-adrenergic receptor kinase (βARK or βARK1), and is a member of the G protein-coupled receptor kinase subfamily of the Ser/Thr protein kinases that is most highly similar to GRK3(βARK2).

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