Benzathine benzylpenicillin

Benzathine benzylpenicillin
Combination of
Benzylpenicillin	antibiotic
Benzathine	stabilizer
Clinical data
Trade names	Bicillin L-A, Permapen, others
Other names	penicillin benzathine benzyl, benzathine penicillin, penicillin G benzathine, benzylpenicillin benzathine
AHFS/Drugs.com	Professional Drug Facts
License data	US DailyMed: Penicillin_G_benzathine;
Pregnancy; category	AU: A;
Routes of; administration	Intramuscular injection
ATC code	J01CE08 (WHO) ;
Legal status
Legal status	US: ℞-only;
Identifiers
CAS Number	41372-02-5 ;
PubChem CID	15232;
DrugBank	DB01053 ;
ChemSpider	14498 ;
UNII	RIT82F58GK;
KEGG	D02157 ;
ChEBI	CHEBI:51352 ;
ChEMBL	ChEMBL3989515 ;
E number	E708 (antibiotics)
CompTox Dashboard (EPA)	DTXSID2047804 ;
ECHA InfoCard	100.014.782
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Benzathine benzylpenicillin, also known as benzathine penicillin G (BPG), is an antibiotic medication useful for the treatment of a number of bacterial infections. Specifically it is used to treat strep throat, diphtheria, syphilis, and yaws. It is also used to prevent rheumatic fever. It is given by injection into a muscle. It is known as "Peanut Butter Shot" in US military slang due to its appearance.

Side effects include allergic reactions including anaphylaxis, and pain at the site of injection. When used to treat syphilis a reaction known as Jarisch-Herxheimer may occur. It is not recommended in those with a history of penicillin allergy or those with syphilis involving the nervous system. Use during pregnancy is generally safe. It is in the penicillin and beta lactam class of medications and works via benzylpenicillin. The benzathine component slowly releases the penicillin making the combination long acting.

Benzathine benzylpenicillin was patented in 1950. It is on the World Health Organization's List of Essential Medicines.

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