Battenin

CLN3
Identifiers
Aliases	CLN3, BTS, JNCL, ceroid-lipofuscinosis, neuronal 3, battenin, BTN1, CLN3 lysosomal/endosomal transmembrane protein, battenin
External IDs	OMIM: 607042 MGI: 107537 HomoloGene: 37259 GeneCards: CLN3
Gene location (Human)
Chr.	Chromosome 16 (human)
End	28,495,575 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	126,585,817 bp
RNA expression pattern
	Top expressed in
	placenta; ; blood; ; monocyte; ; rectum; ; left adrenal gland; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; body of stomach; ; bone marrow cells; ; right lung;
	Top expressed in
	morula; ; yolk sac; ; lip; ; internal carotid artery; ; external carotid artery; ; placenta; ; superior frontal gyrus; ; thymus; ; secondary oocyte; ; islet of Langerhans;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	unfolded protein binding; protein binding;
Cellular component	cytoplasm; integral component of membrane; endosome; late endosome; Golgi apparatus; membrane; synaptic vesicle; Golgi membrane; plasma membrane; autophagosome; lysosomal membrane; integral component of endoplasmic reticulum membrane; trans-Golgi network; early endosome; endoplasmic reticulum; mitochondrion; caveola; membrane raft; neuron projection; Golgi stack; lysosome; nucleus;
Biological process	negative regulation of neuron apoptotic process; negative regulation of proteolysis; lysosomal lumen acidification; negative regulation of catalytic activity; galactosylceramide metabolic process; associative learning; regulation of cytosolic calcium ion concentration; neuromuscular process controlling balance; ceramide metabolic process; vesicle transport along microtubule; cellular amino acid metabolic process; neurotransmitter metabolic process; protein processing; negative regulation of apoptotic process; receptor-mediated endocytosis; lysosomal lumen pH elevation; globoside metabolic process; glucosylceramide metabolic process; autophagosome maturation; protein catabolic process; ionotropic glutamate receptor signaling pathway; action potential; membrane organization; lysosome organization; macroautophagy; amyloid precursor protein catabolic process; sphingomyelin metabolic process; vacuolar transport; transport; regulation of intracellular pH;
	Sources:Amigo / QuickGO
Orthologs
	1201
	12752
	ENSG00000188603
	ENSMUSG00000030720
	Q13286
	Q61124
NM_001286110; NM_000086; NM_001042432; NM_001286104; NM_001286105;
	NM_001286109
	NM_001146311; NM_009907; NM_001329789
NP_000077; NP_001035897; NP_001273033; NP_001273034; NP_001273038;
	NP_001273039
NP_001139783; NP_001316718; NP_034037; NP_001389644; NP_001389645;
	NP_001389646; NP_001389647; NP_001389648; NP_001389649; NP_001389650; NP_001389651
	Wikidata
View/Edit Human	View/Edit Mouse

Battenin is a protein that in humans is encoded by the CLN3 gene located on chromosome 16. Battenin is not clustered into any Pfam clan, but it is included in the TCDB suggesting that it is a transporter. In humans, it belongs to the atypical SLCs due to its structural and phylogenetic similarity to other SLC transporters.

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