B-cell maturation antigen

Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

BCMA TALL-1 binding domain
BCMA TALL-1 binding domain
	crystal structure of stall-1 and bcma
Identifiers
Symbol	BCMA-Tall_bind
Pfam	PF09257
InterPro	IPR015337
SCOP2	1oqd / SCOPe / SUPFAM
Pfam
Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

TNFRSF17
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1OQD, 1XU2, 2KN1, 4ZFO
Identifiers
Aliases	TNFRSF17, BCM, BCMA, CD269, TNFRSF13A, tumor necrosis factor receptor superfamily member 17, TNF receptor superfamily member 17
External IDs	OMIM: 109545 MGI: 1343050 HomoloGene: 920 GeneCards: TNFRSF17
Gene location (Human)
Chr.	Chromosome 16 (human)
End	11,968,068 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	11,137,938 bp
RNA expression pattern
	Top expressed in
	rectum; ; jejunal mucosa; ; lymph node; ; appendix; ; spleen; ; duodenum; ; bone marrow cells; ; thymus; ; spongy bone; ; pylorus;
	Top expressed in
	morula; ; duodenum; ; jejunum; ; spleen; ; lip; ; thymus; ; secondary oocyte; ; colon; ; ileum; ; esophagus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	signaling receptor activity;
Cellular component	endomembrane system; plasma membrane; membrane; integral component of membrane;
Biological process	multicellular organism development; tumor necrosis factor-mediated signaling pathway; lymphocyte homeostasis; cell population proliferation; immune system process; adaptive immune response; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	608
	21935
	ENSG00000048462
	ENSMUSG00000022496
	Q02223
	O88472
	NM_001192
	NM_011608
	NP_001183
	NP_035738
	Wikidata
View/Edit Human	View/Edit Mouse

B-cell maturation antigen (BCMA or BCM), also known as tumor necrosis factor receptor superfamily member 17 (TNFRSF17), is a protein that in humans is encoded by the TNFRSF17 gene.

TNFRSF17 is a cell surface receptor of the TNF receptor superfamily which recognizes B-cell activating factor (BAFF).

Serum B-cell maturation antigen (sBCMA) is the cleaved form of BCMA, found at low levels in the serum of normal patients and generally elevated in patients with multiple myeloma (MM).

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.