Azelaic acid

Azelaic acid (AzA) is an organic compound with the formula HOOC(CH2)7COOH. This saturated dicarboxylic acid exists as a white powder. It is found in wheat, rye, and barley. It is a precursor to diverse industrial products including polymers and plasticizers, as well as being a component of a number of hair and skin conditioners. AzA inhibits tyrosinase.

Azelaic acid
Names
Preferred IUPAC name
Nonanedioic acid
Identifiers
3D model (JSmol)
1101094
ChEBI
ChEMBL
ChemSpider
DrugBank
ECHA InfoCard 100.004.246
EC Number
  • 204-669-1
261342
KEGG
PubChem CID
UNII
  • InChI=1S/C9H16O4/c10-8(11)6-4-2-1-3-5-7-9(12)13/h1-7H2,(H,10,11)(H,12,13) Y
    Key: BDJRBEYXGGNYIS-UHFFFAOYSA-N Y
  • InChI=1/C9H16O4/c10-8(11)6-4-2-1-3-5-7-9(12)13/h1-7H2,(H,10,11)(H,12,13)
    Key: BDJRBEYXGGNYIS-UHFFFAOYAK
SMILES
  • O=C(O)CCCCCCCC(=O)O
Properties
C9H16O4
Molar mass 188.22 g/mol
Appearance white solid
Density 1.443 g/mL
Melting point 109 to 111 °C (228 to 232 °F; 382 to 384 K)
Boiling point 286 °C (547 °F; 559 K) at 100 mmHg
2.14 g/L
Acidity (pKa) 4.550, 5.498
Pharmacology
D10AX03 (WHO)
Routes of
administration
Topical
Pharmacokinetics:
Very low
12 h
Legal status
  • AU: S2 (Pharmacy Only)
  • US: ℞-only
Hazards
GHS labelling:
Warning
H315, H319
P264, P280, P302+P352, P305+P351+P338, P321, P332+P313, P337+P313, P362
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Y verify (what is YN ?)
Infobox references
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