Aromatase

CYP19A1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3EQM, 3S79, 3S7S, 4GL5, 4GL7, 4KQ8
Identifiers
Aliases	CYP19A1, ARO, ARO1, CPV1, CYAR, CYP19, CYPXIX, P-450AROM, cytochrome P450 family 19 subfamily A member 1
External IDs	OMIM: 107910 MGI: 88587 HomoloGene: 30955 GeneCards: CYP19A1
Gene location (Human)
Chr.	Chromosome 15 (human)
End	51,338,601 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	54,175,394 bp
RNA expression pattern
	Top expressed in
	placenta; ; tibial nerve; ; germinal epithelium; ; subcutaneous adipose tissue; ; left coronary artery; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; right adrenal gland; ; left adrenal gland; ; right coronary artery;
	Top expressed in
	spermatocyte; ; secondary oocyte; ; cumulus cell; ; spermatid; ; meninges; ; testicle; ; seminiferous tubule; ; ganglionic eminence; ; amygdala; ; brain stem;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	iron ion binding; oxygen binding; metal ion binding; monooxygenase activity; heme binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; electron transfer activity; oxidoreductase activity; aromatase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; steroid hydroxylase activity;
Cellular component	endoplasmic reticulum membrane; endoplasmic reticulum; membrane; integral component of membrane;
Biological process	estrogen biosynthetic process; androgen metabolic process; negative regulation of chronic inflammatory response; prostate gland growth; sterol metabolic process; negative regulation of macrophage chemotaxis; steroid biosynthetic process; female gonad development; female genitalia development; mammary gland development; uterus development; testosterone biosynthetic process; androgen catabolic process; positive regulation of estradiol secretion; electron transport chain;
	Sources:Amigo / QuickGO
Orthologs
	1588
	13075
	ENSG00000137869
	ENSMUSG00000032274
	P11511
	P28649
NM_000103; NM_001347248; NM_001347249; NM_001347250; NM_001347251;
	NM_001347252; NM_001347253; NM_001347254; NM_001347255; NM_001347256; NM_031226
	NM_007810; NM_001348171; NM_001348172; NM_001348173
NP_000094; NP_001334177; NP_001334178; NP_001334179; NP_001334180;
	NP_001334181; NP_001334182; NP_001334183; NP_001334184; NP_001334185; NP_112503
	NP_001335100; NP_001335101; NP_001335102; NP_031836
	Wikidata
View/Edit Human	View/Edit Mouse

Aromatase (EC 1.14.14.14), also called estrogen synthetase or estrogen synthase, is an enzyme responsible for a key step in the biosynthesis of estrogens. It is CYP19A1, a member of the cytochrome P450 superfamily, which are monooxygenases that catalyze many reactions involved in steroidogenesis. In particular, aromatase is responsible for the aromatization of androgens into estrogens. The enzyme aromatase can be found in many tissues including gonads (granulosa cells), brain, adipose tissue, placenta, blood vessels, skin, and bone, as well as in tissue of endometriosis, uterine fibroids, breast cancer, and endometrial cancer. It is an important factor in sexual development.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.