Armodafinil

Armodafinil
Clinical data
Trade names	Nuvigil, others
AHFS/Drugs.com	Monograph
MedlinePlus	a602016
Pregnancy; category	C;
Dependence; liability	Low
Routes of; administration	Oral (tablets)
ATC code	N06BA13 (WHO) ;
Legal status
Legal status	AU: S4 (Prescription only); BR: Class B1 (Psychoactive drugs); US: Schedule IV;
Pharmacokinetic data
Metabolism	Liver, including CYP3A4 and other pathways
Elimination half-life	15 hours
Excretion	Urine (as metabolites)
Identifiers
	IUPAC name (–)-2-[(R)-(diphenylmethyl)sulfinyl]acetamide;
CAS Number	112111-43-0 ;
PubChem CID	9690109;
ChemSpider	7962943 ;
UNII	V63XWA605I;
KEGG	D03215 ;
ChEBI	CHEBI:77590 ;
ChEMBL	ChEMBL1201192 ;
CompTox Dashboard (EPA)	DTXSID90920667 ;
ECHA InfoCard	100.207.833
Chemical and physical data
Formula	C15H15NO2S
Molar mass	273.35 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1=CC=C(C=C1)C(C2=CC=CC=C2)[S@](=O)CC(=O)N;
	InChI InChI=1S/C15H15NO2S/c16-14(17)11-19(18)15(12-7-3-1-4-8-12)13-9-5-2-6-10-13/h1-10,15H,11H2,(H2,16,17)/t19-/m1/s1 ; Key:YFGHCGITMMYXAQ-LJQANCHMSA-N ;
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Armodafinil (trade name Nuvigil) is the enantiopure compound of the eugeroic modafinil (Provigil). It consists of only the (R)-(−)-enantiomer of the racemic modafinil. Armodafinil is produced by the pharmaceutical company Cephalon Inc. and was approved by the U.S. Food and Drug Administration (FDA) in June 2007. In 2016, the FDA granted Mylan rights for the first generic version of Cephalon's Nuvigil to be marketed in the U.S.

Because armodafinil has a longer half-life than modafinil does, it may be more effective at improving wakefulness in patients with excessive daytime sleepiness.

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