Aquaporin-1

AQP1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4CSK, 1FQY, 1H6I, 1IH5
Identifiers
Aliases	AQP1, AQP-CHIP, CHIP28, CO, aquaporin 1 (Colton blood group)
External IDs	OMIM: 107776 MGI: 103201 HomoloGene: 68051 GeneCards: AQP1
Gene location (Human)
Chr.	Chromosome 7 (human)
End	30,925,517 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	55,325,540 bp
RNA expression pattern
	Top expressed in
	ascending aorta; ; right lung; ; upper lobe of left lung; ; right coronary artery; ; pericardium; ; kidney; ; lower lobe of lung; ; left coronary artery; ; gastric mucosa; ; renal medulla;
	Top expressed in
	right lung; ; right lung lobe; ; ankle; ; fourth ventricle; ; left lung; ; rib; ; kidney; ; body of femur; ; digastric muscle; ; left lung lobe;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transporter activity; ammonium transmembrane transporter activity; nitric oxide transmembrane transporter activity; intracellular cGMP-activated cation channel activity; potassium channel activity; transmembrane transporter activity; carbon dioxide transmembrane transporter activity; protein binding; water transmembrane transporter activity; potassium ion transmembrane transporter activity; glycerol transmembrane transporter activity; water channel activity; ephrin receptor binding; identical protein binding; channel activity;
Cellular component	cytoplasm; nuclear membrane; symbiont-containing vacuole membrane; membrane; nucleus; apical plasma membrane; integral component of membrane; plasma membrane; apical part of cell; basal plasma membrane; integral component of plasma membrane; brush border membrane; basolateral plasma membrane; sarcolemma; brush border; symbiont-containing vacuole; axon; neuron projection; axon terminus; extracellular exosome;
Biological process	cellular response to retinoic acid; cellular response to mechanical stimulus; cellular response to copper ion; cellular response to nitric oxide; cellular response to hypoxia; cellular response to cAMP; carbon dioxide transmembrane transport; positive regulation of fibroblast proliferation; cellular homeostasis; pancreatic juice secretion; cGMP biosynthetic process; cellular response to stress; cellular response to salt stress; cellular response to inorganic substance; cell volume homeostasis; cellular response to UV; establishment or maintenance of actin cytoskeleton polarity; negative regulation of apoptotic process; cellular response to dexamethasone stimulus; positive regulation of angiogenesis; odontogenesis; renal water transport; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; cellular response to mercury ion; nitric oxide transport; cellular hyperosmotic response; bicarbonate transport; positive regulation of saliva secretion; renal water homeostasis; multicellular organismal water homeostasis; transepithelial water transport; carbon dioxide transport; cellular response to hydrogen peroxide; cerebrospinal fluid secretion; potassium ion transmembrane transport; ammonium transmembrane transport; cation transmembrane transport; glomerular filtration; potassium ion transport; water transport; hyperosmotic response; response to hormone; positive regulation of lamellipodium assembly; positive regulation of epithelial cell migration; glycerol transport; sensory perception of pain; lateral ventricle development; water homeostasis; positive regulation of cell migration; secretion by cell; secretory granule organization; wound healing; hyperosmotic salinity response; response to estrogen; lipid digestion; camera-type eye morphogenesis; corticotropin secretion; renal water absorption; metanephric descending thin limb development; metanephric proximal straight tubule development; metanephric proximal convoluted tubule segment 2 development; metanephric glomerulus vasculature development; transport; cGMP-mediated signaling; ion transmembrane transport; transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	358
	11826
	ENSG00000240583
	ENSMUSG00000004655
	P29972; Q6JSD8; Q6JSD7
	Q02013
NM_198098; NM_000385; NM_001185060; NM_001185061; NM_001185062;
	NM_001329872
	NM_007472
	NP_001316801; NP_932766
	NP_031498
	Wikidata
View/Edit Human	View/Edit Mouse

Aquaporin 1 (AQP-1) is a protein that in humans is encoded by the AQP1 gene.

AQP-1 is a widely expressed water channel, whose physiological function has been most thoroughly characterized in the kidney. It is found in the basolateral and apical plasma membranes of the proximal tubules, the descending limb of the loop of Henle, and in the descending portion of the vasa recta. Additionally, it is found in red blood cells, vascular endothelium, the gastrointestinal tract, sweat glands, lungs, and the central nervous system.

Neural AQP-1 receptors are regulated by vasopressin AVPR1A receptor activity.

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