Alpha 2-antiplasmin

SERPINF2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2R9Y
Identifiers
Aliases	SERPINF2, A2AP, AAP, ALPHA-2-PI, API, PLI, serpin family F member 2, alpha2AP
External IDs	OMIM: 613168 MGI: 107173 HomoloGene: 719 GeneCards: SERPINF2
Gene location (Human)
Chr.	Chromosome 17 (human)
End	1,755,265 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	75,330,417 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; kidney; ; left uterine tube; ; prostate; ; upper lobe of left lung; ; right lobe of thyroid gland; ; myometrium; ; subcutaneous adipose tissue; ; popliteal artery; ; gastric mucosa;
	Top expressed in
	yolk sac; ; liver; ; proximal tubule; ; left lobe of liver; ; kidney; ; gallbladder; ; abdominal wall; ; sexually immature organism; ; ureter; ; stomach;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	peptidase inhibitor activity; protein homodimerization activity; protease binding; protein binding; serine-type endopeptidase inhibitor activity; endopeptidase inhibitor activity;
Cellular component	blood microparticle; fibrinogen complex; extracellular region; cell surface; extracellular exosome; platelet alpha granule lumen; extracellular space; collagen-containing extracellular matrix;
Biological process	positive regulation of collagen biosynthetic process; negative regulation of peptidase activity; negative regulation of fibrinolysis; negative regulation of plasminogen activation; maintenance of blood vessel diameter homeostasis by renin-angiotensin; blood vessel morphogenesis; fibrinolysis; collagen fibril organization; platelet degranulation; positive regulation of JNK cascade; response to organic substance; acute-phase response; positive regulation of cell differentiation; positive regulation of ERK1 and ERK2 cascade; positive regulation of transforming growth factor beta production; positive regulation of stress fiber assembly; positive regulation of transcription by RNA polymerase II; positive regulation of smooth muscle cell proliferation; positive regulation of cell-cell adhesion mediated by cadherin; negative regulation of endopeptidase activity;
	Sources:Amigo / QuickGO
Orthologs
	5345
	18816
	ENSG00000167711; ENSG00000276838
	ENSMUSG00000038224
	P08697
	Q61247
	NM_000934; NM_001165920; NM_001165921
	NM_008878
	NP_000925; NP_001159392; NP_001159393
	NP_032904
	Wikidata
View/Edit Human	View/Edit Mouse

Alpha 2-antiplasmin (or α₂-antiplasmin or plasmin inhibitor) is a serine protease inhibitor (serpin) responsible for inactivating plasmin. Plasmin is an important enzyme that participates in fibrinolysis and degradation of various other proteins. This protein is encoded by the SERPINF2 gene.

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