Anti-topoisomerase antibodies
Anti-topoisomerase antibodies (ATA) are autoantibodies directed against topoisomerase and found in several diseases, most importantly scleroderma. Diseases with ATA are autoimmune disease because they react with self-proteins. They are also referred to as anti-DNA topoisomerase I antibody (anti-topo I).
| Autoantibody | |
|---|---|
| Anti-Topoisomerase | |
| Autoantigen Isoform | Topoisomerase I (human) |
| Autoantigen gene | TOP1 |
| Affected organ(s) | Dermis |
| Associated Disease(s) | Scleroderma,
Systemic sclerosis |
| Autoantibody Ig Class | IgG, IgA |
| DR2 | |
| HLA associations | DR15 |
| DR16 | |
| Other Susceptibility genes | lymphoid protein tyrosine phos- |
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