Anti-AQP4 disease
Anti-AQP4 diseases, are a group of diseases characterized by auto-antibodies against aquaporin 4.
| Anti-AQP4 disease | |
|---|---|
| Other names | Neuromyelitis optica spectrum of diseases |
After the discovery of anti-AQP4 autoantibody in neuromyelitis optica, it was found that it was also present in some patients with other clinically defined diseases, including multiple sclerosis variants like optic-spinal MS.
The collection of these condition has been named "anti-AQP4 disease" and "neuromyelitis optica spectrum disorders" (NMSD) and they are expected to respond to the same treatments as standard NMO. Some authors propose to use the name "autoimmune aquaporin-4 channelopathy" for these diseases, while others prefer a more generic term "AQP4-astrocytopathy" that includes also problems in AQP4 with a non-autoimmune origin.
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