Amperozide

Amperozide
Clinical data
ATCvet code	QN05AX90 (WHO) ;
Identifiers
	IUPAC name 4-[4,4-bis(4-fluorophenyl)butyl]-N-ethylpiperazine-1-carboxamide;
CAS Number	75558-90-6 ;
PubChem CID	73333;
ChemSpider	66062 ;
UNII	0M2W3TAG39;
ChEMBL	ChEMBL1079935 ;
CompTox Dashboard (EPA)	DTXSID6048416 ;
Chemical and physical data
Formula	C23H29F2N3O
Molar mass	401.502 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCNC(=O)N1CCN(CC1)CCCC(C2=CC=C(C=C2)F)C3=CC=C(C=C3)F;
	InChI InChI=1S/C23H29F2N3O/c1-2-26-23(29)28-16-14-27(15-17-28)13-3-4-22(18-5-9-20(24)10-6-18)19-7-11-21(25)12-8-19/h5-12,22H,2-4,13-17H2,1H3,(H,26,29) ; Key:NNAIYOXJNVGUOM-UHFFFAOYSA-N ;
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Amperozide is an atypical antipsychotic of the diphenylbutylpiperazine class which acts as an antagonist at the 5-HT_2A receptor. It does not block dopamine receptors as with most antipsychotic drugs, but does inhibit dopamine release, and alters the firing pattern of dopaminergic neurons. It was investigated for the treatment of schizophrenia in humans, but never adopted clinically. Its main use is instead in veterinary medicine, primarily in intensively farmed pigs, for decreasing aggression and stress and thereby increasing feeding and productivity.

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