Amiodarone
Amiodarone is an antiarrhythmic medication used to treat and prevent a number of types of cardiac dysrhythmias. This includes ventricular tachycardia (VT), ventricular fibrillation (VF), and wide complex tachycardia, as well as atrial fibrillation and paroxysmal supraventricular tachycardia. Evidence in cardiac arrest, however, is poor. It can be given by mouth, intravenously, or intraosseously. When used by mouth, it can take a few weeks for effects to begin.
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| Pronunciation | /ˌæmiˈoʊdəroʊn/ or /əˈmiːoʊdəˌroʊn/ |
| Trade names | Cordarone, Nexterone, Pacerone, others |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a687009 |
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| Routes of administration | By mouth, intravenous, intraosseous |
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| Bioavailability | 20–55% |
| Protein binding | 96% |
| Metabolism | Liver |
| Elimination half-life | 58 d (range 15–142 d) |
| Excretion | Primarily liver and bile |
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| ECHA InfoCard | 100.016.157 |
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| Formula | C25H29I2NO3 |
| Molar mass | 645.320 g·mol−1 |
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Common side effects include feeling tired, tremor, nausea, and constipation. As amiodarone can have serious side effects, it is mainly recommended only for significant ventricular arrhythmias. Serious side effects include lung toxicity such as interstitial pneumonitis, liver problems, heart arrhythmias, vision problems, thyroid problems, and death. If taken during pregnancy or breastfeeding it can cause problems in the fetus or the infant. It is a class III antiarrhythmic medication. It works partly by increasing the time before a heart cell can contract again.
Amiodarone was first made in 1961 and came into medical use in 1962 for chest pain believed to be related to the heart. It was pulled from the market in 1967 due to side effects. In 1974 it was found to be useful for arrhythmias and reintroduced. It is on the World Health Organization's List of Essential Medicines. It is available as a generic medication. In 2021, it was the 235th most commonly prescribed medication in the United States, with more than 1 million prescriptions.