Alphacoronavirus
Alphacoronaviruses (Alpha-CoV) are members of the first of the four genera (Alpha-, Beta-, Gamma-, and Delta-) of coronaviruses. They are positive-sense, single-stranded RNA viruses that infect mammals, including humans. They have spherical virions with club-shaped surface projections formed by trimers of the spike protein, and a viral envelope.
| Alphacoronavirus | |
|---|---|
| Porcine epidemic diarrhea virus genome and virion structure | |
| Virus classification | |
| (unranked): | Virus |
| Realm: | Riboviria |
| Kingdom: | Orthornavirae |
| Phylum: | Pisuviricota |
| Class: | Pisoniviricetes |
| Order: | Nidovirales |
| Family: | Coronaviridae |
| Subfamily: | Orthocoronavirinae |
| Genus: | Alphacoronavirus |
| Subgenera and species | |
Alphacoronaviruses are in the subfamily Orthocoronavirinae of the family Coronaviridae. Both the Alpha- and Betacoronavirus lineages descend from the bat viral gene pool. Alphacoronaviruses were previously known as "phylogroup 1 coronaviruses".
The Alphacoronavirus genus is very diverse, particularly in bats. Most bat originating strains haven't been successfully isolated and cultured in laboratory. Alphacoronaviruses infecting other mammal species have been much better studied, see List of Coronavirus live isolates.