Alpha-enolase

ENO1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2PSN, 3B97
Identifiers
Aliases	ENO1, ENO1L1, MPB1, NNE, PPH, HEL-S-17, enolase 1
External IDs	OMIM: 172430 MGI: 95393 HomoloGene: 134343 GeneCards: ENO1
Gene location (Human)
Chr.	Chromosome 1 (human)
End	8,879,190 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	150,333,336 bp
RNA expression pattern
	Top expressed in
	nucleus accumbens; ; Achilles tendon; ; renal medulla; ; putamen; ; smooth muscle tissue; ; embryo; ; ascending aorta; ; caudate nucleus; ; amygdala; ; Brodmann area 9;
	Top expressed in
	neural tube; ; lens; ; mesencephalon; ; proximal tubule; ; hippocampus proper; ; esophagus; ; rhombencephalon; ; stomach; ; jejunum; ; cerebellar cortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; metal ion binding; protein binding; lyase activity; GTPase binding; magnesium ion binding; RNA binding; cadherin binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; phosphopyruvate hydratase activity; protein homodimerization activity; RNA polymerase II transcription regulatory region sequence-specific DNA binding;
Cellular component	cytoplasm; M band; membrane; extracellular exosome; nucleus; extracellular space; phosphopyruvate hydratase complex; cytosol; plasma membrane; cell surface; cell cortex region;
Biological process	gluconeogenesis; regulation of transcription, DNA-templated; glycolytic process; response to virus; transcription, DNA-templated; negative regulation of cell growth; negative regulation of transcription, DNA-templated; negative regulation of transcription by RNA polymerase II; positive regulation of plasminogen activation; positive regulation of muscle contraction; canonical glycolysis; negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway; positive regulation of ATP biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	2023
	13806
	ENSG00000074800
	ENSMUSG00000063524
	P06733
	P17182
	NM_001201483; NM_001428; NM_001353346
	NM_023119; NM_001379127; NM_001379128
	NP_001188412; NP_001419; NP_001340275
	NP_001366056; NP_001366057; NP_075608; NP_001020559
	Wikidata
View/Edit Human	View/Edit Mouse

Enolase 1 (ENO1), more commonly known as alpha-enolase, is a glycolytic enzyme expressed in most tissues, one of the isozymes of enolase. Each isoenzyme is a homodimer composed of 2 alpha, 2 gamma, or 2 beta subunits, and functions as a glycolytic enzyme. Alpha-enolase, in addition, functions as a structural lens protein (tau-crystallin) in the monomeric form. Alternative splicing of this gene results in a shorter isoform that has been shown to bind to the c-myc promoter and function as a tumor suppressor. Several pseudogenes have been identified, including one on the long arm of chromosome 1. Alpha-enolase has also been identified as an autoantigen in Hashimoto encephalopathy.

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