Alpha-2A adrenergic receptor

ADRA2A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1HLL, 1HO9, 1HOD, 1HOF
Identifiers
Aliases	ADRA2A, ADRA2, ADRA2R, ADRAR, ALPHA2AAR, ZNF32, adrenoceptor alpha 2A
External IDs	OMIM: 104210 MGI: 87934 HomoloGene: 47944 GeneCards: ADRA2A
Gene location (Human)
Chr.	Chromosome 10 (human)
End	111,080,907 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	54,037,413 bp
RNA expression pattern
	Top expressed in
	subcutaneous adipose tissue; ; canal of the cervix; ; pericardium; ; gallbladder; ; ganglionic eminence; ; body of pancreas; ; abdominal fat; ; germinal epithelium; ; pancreatic ductal cell; ; lymph node;
	Top expressed in
	pontine nuclei; ; islet of Langerhans; ; dorsomedial hypothalamic nucleus; ; subiculum; ; mammillary body; ; medullary collecting duct; ; conjunctival fornix; ; lateral hypothalamus; ; anterior horn of spinal cord; ; inferior colliculus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	alpha-2C adrenergic receptor binding; G protein-coupled receptor activity; protein homodimerization activity; epinephrine binding; norepinephrine binding; alpha-1B adrenergic receptor binding; signal transducer activity; adrenergic receptor activity; protein binding; alpha2-adrenergic receptor activity; protein heterodimerization activity; thioesterase binding; heterotrimeric G-protein binding; protein kinase binding;
Cellular component	integral component of membrane; membrane; receptor complex; plasma membrane; integral component of plasma membrane; basolateral plasma membrane; cytoplasm;
Biological process	G protein-coupled receptor signaling pathway; positive regulation of epidermal growth factor-activated receptor activity; activation of protein kinase B activity; negative regulation of insulin secretion; positive regulation of MAP kinase activity; negative regulation of epinephrine secretion; glucose homeostasis; regulation of smooth muscle contraction; positive regulation of cytokine production; regulation of insulin secretion; positive regulation of cell migration; positive regulation of potassium ion transport; phospholipase C-activating adrenergic receptor signaling pathway; positive regulation of wound healing; negative regulation of norepinephrine secretion; positive regulation of membrane protein ectodomain proteolysis; negative regulation of insulin secretion involved in cellular response to glucose stimulus; adenylate cyclase-inhibiting adrenergic receptor signaling pathway; negative regulation of calcium ion transmembrane transporter activity; cellular response to hormone stimulus; regulation of vasoconstriction; negative regulation of calcium ion-dependent exocytosis; Rho protein signal transduction; positive regulation of cell population proliferation; negative regulation of calcium ion transport; intestinal absorption; Ras protein signal transduction; negative regulation of lipid catabolic process; activation of protein kinase activity; actin cytoskeleton organization; signal transduction; platelet activation; positive regulation of MAPK cascade; adrenergic receptor signaling pathway; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; adenylate cyclase-activating G protein-coupled receptor signaling pathway; adenylate cyclase-activating adrenergic receptor signaling pathway; receptor transactivation; adenylate cyclase-modulating G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	150
	11551
	ENSG00000150594
	ENSMUSG00000033717
	P08913
	Q01338
	NM_000681
	NM_007417
	NP_000672
	NP_031443
	Wikidata
View/Edit Human	View/Edit Mouse

The alpha-2A adrenergic receptor (α_2A adrenoceptor), also known as ADRA2A, is an α₂ adrenergic receptor, and also denotes the human gene encoding it.

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