Aldosterone synthase

CYP11B2
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	4DVQ, 4FDH, 4ZGX
Identifiers
Aliases	CYP11B2, ALDOS, CPN2, CYP11B, CYP11BL, CYPXIB2, P-450C18, P450C18, P450aldo, cytochrome P450 family 11 subfamily B member 2
External IDs	OMIM: 124080 MGI: 88583 HomoloGene: 106948 GeneCards: CYP11B2
EC number	1.14.15.4
Gene location (Human)
Chr.	Chromosome 8 (human)
End	142,917,843 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	74,713,492 bp
RNA expression pattern
	Top expressed in
	left adrenal gland; ; fundus; ; connective tissue; ; adipose tissue; ; heart; ; atrium; ; right atrium; ; thoracic aorta; ; ascending aorta; ; limb;
	Top expressed in
	adrenal gland; ; belly cord; ; spinal ganglia; ; extraocular muscle; ; upper arm; ; triceps brachii muscle; ; ureter; ; testicle; ; uterus; ; kidney;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	iron ion binding; corticosterone 18-monooxygenase activity; metal ion binding; monooxygenase activity; heme binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; oxidoreductase activity; steroid 11-beta-monooxygenase activity; steroid hydroxylase activity;
Cellular component	mitochondrial membranes; membrane; mitochondrion; mitochondrial inner membrane;
Biological process	lipid metabolism; aldosterone biosynthetic process; cortisol biosynthetic process; C21-steroid hormone biosynthetic process; cellular response to hormone stimulus; potassium ion homeostasis; mineralocorticoid biosynthetic process; regulation of blood volume by renal aldosterone; renal water homeostasis; sterol metabolic process; sodium ion homeostasis; cellular response to potassium ion; steroid biosynthetic process; steroid metabolic process; glucocorticoid biosynthetic process; cholesterol metabolic process; cellular response to peptide hormone stimulus; cortisol metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	1585
	110115
	ENSG00000179142
	ENSMUSG00000075604
	P19099
	n/a
	NM_000498
	NM_001033229
	NP_000489
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Aldosterone synthase, also called steroid 18-hydroxylase, corticosterone 18-monooxygenase or P450C18, is a steroid hydroxylase cytochrome P450 enzyme involved in the biosynthesis of the mineralocorticoid aldosterone and other steroids. The enzyme catalyzes sequential hydroxylations of the steroid angular methyl group at C18 after initial 11β-hydroxylation (the enzyme has steroid 18-hydroxylase activity as well as steroid 11 beta-hydroxylase activity). It is encoded by the CYP11B2 gene in humans.

Aldosterone synthase is a protein which is only expressed in the zona glomerulosa of the adrenal cortex and is primarily regulated by the renin–angiotensin system. It is the sole enzyme capable of synthesizing aldosterone in humans and plays an important role in electrolyte balance and blood pressure.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.