Aldolase C

ALDOC
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1XFB
Identifiers
Aliases	ALDOC, ALDC, Aldolase C, aldolase, fructose-bisphosphate C
External IDs	OMIM: 103870 MGI: 101863 HomoloGene: 21073 GeneCards: ALDOC
Gene location (Human)
Chr.	Chromosome 17 (human)
End	28,576,948 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	78,218,607 bp
RNA expression pattern
	Top expressed in
	pons; ; amygdala; ; nucleus accumbens; ; cingulate gyrus; ; Brodmann area 9; ; superior vestibular nucleus; ; external globus pallidus; ; putamen; ; prefrontal cortex; ; cerebellar vermis;
	Top expressed in
	cerebellar vermis; ; medial vestibular nucleus; ; dorsal tegmental nucleus; ; pontine nuclei; ; motor neuron; ; corpora quadrigemina; ; inferior colliculus; ; superior colliculus; ; globus pallidus; ; medial geniculate nucleus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	cytoskeletal protein binding; protein binding; catalytic activity; lyase activity; fructose-bisphosphate aldolase activity;
Cellular component	cytosol; extracellular exosome; cytoskeleton; mitochondrion; extracellular region; secretory granule lumen; tertiary granule lumen; ficolin-1-rich granule lumen;
Biological process	gluconeogenesis; fructose metabolic process; glycolytic process; epithelial cell differentiation; canonical glycolysis; fructose 1,6-bisphosphate metabolic process; neutrophil degranulation;
	Sources:Amigo / QuickGO
Orthologs
	230
	11676
	ENSG00000109107
	ENSMUSG00000017390
	P09972
	P05063
	NM_005165
	NM_009657; NM_001303423
	NP_005156
	NP_001290352; NP_033787
	Wikidata
View/Edit Human	View/Edit Mouse

Aldolase C, fructose-bisphosphate (ALDOC, or ALDC), is an enzyme that, in humans, is encoded by the ALDOC gene on chromosome 17. This gene encodes a member of the class I fructose-bisphosphate aldolase gene family. Expressed specifically in the hippocampus and Purkinje cells of the brain, the encoded protein is a glycolytic enzyme that catalyzes the reversible aldol cleavage of fructose 1,6-bisphosphate and fructose-1-phosphate to dihydroxyacetone phosphate and either glyceraldehyde 3-phosphate or glyceraldehyde, respectively.[provided by RefSeq, Jul 2008]

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