Aldo-keto reductase family 1, member A1

AKR1A1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2ALR
Identifiers
Aliases	AKR1A1, ALDR1, ALR, ARM, DD3, HEL-S-6, Aldo-keto reductase family 1, member A1, aldo-keto reductase family 1, member A1 (aldehyde reductase), aldo-keto reductase family 1 member A1
External IDs	OMIM: 103830 MGI: 1929955 HomoloGene: 74565 GeneCards: AKR1A1
Gene location (Human)
Chr.	Chromosome 1 (human)
End	45,570,049 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	116,508,877 bp
RNA expression pattern
	Top expressed in
	kidney tubule; ; right lobe of liver; ; palpebral conjunctiva; ; kidney; ; body of pancreas; ; glomerulus; ; parotid gland; ; metanephric glomerulus; ; duodenum; ; jejunal mucosa;
	Top expressed in
	barrel cortex; ; medullary collecting duct; ; external carotid artery; ; utricle; ; superior cervical ganglion; ; condyle; ; conjunctival fornix; ; iris; ; fossa; ; internal carotid artery;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	alditol:NADP+ 1-oxidoreductase activity; electron transfer activity; oxidoreductase activity; alcohol dehydrogenase (NADP+) activity; protein binding; aldo-keto reductase (NADP) activity; L-glucuronate reductase activity; glucuronolactone reductase activity; NAD-retinol dehydrogenase activity; allyl-alcohol dehydrogenase activity;
Cellular component	cytosol; extracellular exosome; apical plasma membrane; extracellular space; synapse; cytoplasm; plasma membrane; membrane;
Biological process	cellular aldehyde metabolic process; aldehyde catabolic process; D-glucuronate catabolic process; L-ascorbic acid biosynthetic process; glutathione derivative biosynthetic process; glucuronate catabolic process to xylulose 5-phosphate; glucose metabolic process; electron transport chain; cellular detoxification of aldehyde; daunorubicin metabolic process; doxorubicin metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	10327
	58810
	ENSG00000117448
	ENSMUSG00000028692
	P14550
	Q9JII6
	NM_001202413; NM_001202414; NM_006066; NM_153326
	NM_021473
	NP_001189342; NP_001189343; NP_006057; NP_697021
	NP_067448
	Wikidata
View/Edit Human	View/Edit Mouse

Alcohol dehydrogenase [NADP+] also known as aldehyde reductase or aldo-keto reductase family 1 member A1 is an enzyme that in humans is encoded by the AKR1A1 gene. AKR1A1 belongs to the aldo-keto reductase (AKR) superfamily. It catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols and catalyzes the reduction of mevaldate to mevalonic acid and of glyceraldehyde to glycerol. Mutations in the AKR1A1 gene has been found associated with non-Hodgkin's lymphoma.

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